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هق...هق!

سكسكه‌ عبارت‌ است‌ از انقباضات‌ ناخودآگاه‌ و مكرر عضله‌ ديافراگم‌. سكسكه‌ يك‌ علامت‌ است‌ و نه‌ يك‌ بيماري‌. در ايجاد سكسكه‌ ديافراگم‌ (عضله‌ بزرگ‌ و نازكي‌ كه‌ قفسه‌ سينه‌ را از شكم‌ جدا مي‌سازد) و عصب‌ فرنيك‌ (عصبي‌ كه‌ ديافراگم‌ را به‌ مغز وصل‌ مي‌كند) نقش‌ دارند. تقريباً همه‌ ممكن‌ است‌ دچار سكسكه‌ شوند، حتي‌ جنيني‌ كه‌ در رحم‌ مادر است‌.

علايم
يك‌ صداي‌ تند و سريع‌ كه‌ در اثر گرفتگي‌ ديافراگم‌ از دهان‌ خارج‌ مي‌شود. اين‌ گرفتگي‌، عضلات‌ ته‌ گلو را به‌ هنگام‌ دم‌ مي‌بندد.

علل
تحريك‌ اعصابي‌ كه‌ عضلات‌ تنفسي‌، خصوصاً ديافراگم‌، را تحريك‌ مي‌كنند. علت‌ سكسكه‌ كوتاه‌مدت‌ معمولاً ناشناخته‌ است‌. در صورتي‌ كه‌ سكسكه‌ طولاني‌مدت‌ باشد يا به‌طور مكرر رخ‌ دهد، امكان‌ دارد به‌ علل‌ زير ايجاد شده‌ باشد:
خوردن‌ يا آشاميدن‌ غذا يا نوشيدني‌ داغ‌ يا مواد تحريك‌كننده‌
بيماري‌هاي‌ پرده‌ جنب‌ (پرده‌ نازكي‌ كه‌ روي‌ ريه‌ها را مي‌پوشاند).
ذات‌الريه‌
اورمي‌ (جمع‌ شدن‌ مواد زايد سمي‌ در اثر نارسايي‌ كليه‌)
الكلي‌ بودن‌
مصرف‌ بعضي‌ از داروها
اختلالات‌ معده‌، مري‌، روده‌ يا لوزالعمده‌
حاملگي‌
تحريك‌ مثانه‌
هپاتيت‌
گسترش‌ سرطان‌ از يك‌ قسمت‌ از بدن‌ به‌ كبد يا قسمتي‌ از پرده‌ جنب‌
سابقه‌ عمل‌ جراحي‌ اخير، خصوصاً جراحي‌ روي‌ شكم‌

درمان
روش‌هايي‌ كه‌ در اين‌ جا ذكر مي‌شوند براي‌ دوره‌هاي‌ كوتاه‌مدت‌ سكسكه‌ هستند. سكسكه‌ طولاني‌مدت‌ بايد تحت‌ بررسي‌ پزشكي‌ قرار گيرد. يك‌ يا تعداد بيشتري‌ از روش‌هاي‌ زير را به‌ كار بنديد تا بهترين‌ آنها براي‌ شما معلوم‌ شود.
نفس‌ خود را نگاه‌ داريد و تا 10 بشماريد.
داخل‌ يك‌ كيسه‌ كاغذي‌ تنفس‌ كنيد. از كيسه‌ پلاستيكي‌ استفاده‌ نكنيد زيرا ممكن‌ است‌ به‌ سوراخ‌ بيني‌ بچسبد.
انگشت‌ شست‌ خود را بين‌ دندان‌ها و لب‌ بالا قرار دهيد. سپس‌ لب‌ بالا را با انگشت‌ سبابه‌ خود، درست‌ در زير سوراخ‌ بيني‌ سمت‌ راست‌، فشار دهيد.
انگشتان‌ سبابه‌ خود را حدود 20 ثانيه‌ داخل‌ هر دو گوش‌ فشاردهيد.
يك‌ ليوان‌ آب‌ را به‌ سرعت‌ بنوشيد.
نان‌ خشك‌ يا يخ‌ خرد شده‌ قورت‌ دهيد.
زبان‌ خود را به‌ ملايمت‌ بكشيد.
بازی '' پول من رو تو برداشتی ؟ '' با طرف (حواس پرت کردن)
چشمان‌ خود را ببنديد و فشار ملايمي‌ را به‌ كره‌هاي‌ چشم‌ وارد كنيد.
يك‌ قاشق‌ چايخوري‌ شكر خشك‌ بخوريد

Posted by نيما ساكتي at | Link To This Post ID 108 | Topic :

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Posted by نيما ساكتي at | Link To This Post ID 168 | Topic :
sandrom terner - dr-dre


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Posted by نيما ساكتي at | Link To This Post ID 165 | Topic : پزشکی(MEDICINE)

Antibiotic

From http://www.glamor.tk/, the free encyclopedia

Jump to: navigation, search
Testing the susceptibility of Staphylococcus aureus to antibiotics by the Kirby-Bauer disk diffusion method. Antibiotics diffuse out from antibiotic-containing disks and inhibit growth of S. aureus resulting in a zone of inhibition.
Testing the susceptibility of Staphylococcus aureus to antibiotics by the Kirby-Bauer disk diffusion method. Antibiotics diffuse out from antibiotic-containing disks and inhibit growth of S. aureus resulting in a zone of inhibition.

 


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Posted by نيما ساكتي at | Link To This Post ID 164 | Topic :

معرفی سایتی مرجع در زمینه نت اتودهای معروف

یکی از سایتهای دانلود نت سایت eythorsson میباشد که زمانی مرجعی بود برای دانلود نت هرچند در حال حاضر سایتهای بسیاری در این زمینه فعال میباشند که در این سایت بسیاری از آنان معرفی شده و در قسمت بانک نت گیتار سایت نیز این سایتهای مرجع ذکر شده اما شاید بتوان گفت بسیاری از این سایتهای تنظیمات خوبی از قطعات را در سایت قرار نمیدهند . و یکی از مهم ترین مشکلات نوازندگان حرفه ای گیتار در ایران نداشتن نت هایی با تنظیمات خوب می باشد.


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Posted by نيما ساكتي at | Link To This Post ID 162 | Topic : موسیقی(MUSIC)

Wigwam قطعه ای برای گیتار کلاسیک

قطعه ای با عنوان Wigwam - آهنگساز فرشاد شعبانی برای گیتار کلاسیک

علاقمندان برای درج قطعات ساخته شده و تنظیم شده خودشان مینوانند با آدرس سایت تماس حاصل فرمایند
prowl.nima@gmail.com

دانلود نت
page 1

page 2

دانلود فایل صوتی
Download

Posted by نيما ساكتي at | Link To This Post ID 161 | Topic : تصویری کلاسک و فلامینکو

قطعات سطح بندی شده گیتار کلاسیک

یکی از مشکلات بسیاری از اساتید و همچنین نوازندگان نداشتن قطعات بصورت سطح بندی از قطعات اسان تا حرفه ای میباشد که در این سطح بندی قطعات به چندین سطح ( ممکن است این سطح بندی تا ده دسته مختلف نیز باشد ) قرار میگیرد.

دانلود کنید ( قابل اجرا با نرم افزار Adobe Acrobat Reader میباشد )

سطح 1
سطح 2
سطح 3
سطح 4

Posted by نيما ساكتي at | Link To This Post ID 160 | Topic : بانک نت (note bank)

افسون بروس اسپرینگستین

بروس اسپرینگستین یکی از زیباترین و ساده‌ترین آلبوم هایش را به تازگی با عنوان «افسون» به بازار فرستاد. آهنگ‌ها ملودیک هستند و ملودی‌ها رمانتیک. مثل همیشه بروس اسپرینگستین داستان می‌گوید.مثل همیشه، داستان آدم‌های متوسط الحال ِآمریکایی که با سادگی و بردباری و طاقت، جان می‌کنند اما در قمار ِخوشبختی آمریکایی سرانجام بازنده می‌شوند.


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Posted by نيما ساكتي at | Link To This Post ID 159 | Topic : موسیقی(MUSIC)

نگاهی به آلبوم‌ها و فعالیت‌های مارک نوفلر، گرداننده گروه پرآوازه دایر استریتز

مارک نوفلر، خواننده و گرداننده گروه اسطوره‌ای دایر استریتز مدتهاست که به شکل سولو فعالیت دارد و به تازگی هم آلبومی جدید منتشر کرده است. آرش سبحانی از گروه محبوب کیوسک از ویژگی‌ها‌ی نوفلر سخن می‌گوید.


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Posted by نيما ساكتي at | Link To This Post ID 158 | Topic : موسیقی(MUSIC)

نگاهی به آلبومها و ویژگی‌های گروه پرآوازه «پلیس

یکی از رویدادهای مهم عالم موسیقی در سال جاری بازگشت گروه پرآوازه «پلیس» به صحنه بود؛ گروهی که در طول عمر نسبتا کوتاه‌اش، با انتشار پنج آلبوم توانست ردپایی عمیق از خود در دنیای پاپ و راک به جای بگذارد.گروه اسطوره‌ای The Police که یکی از موفقترین و محبوبترین گروه‌های اواخر دهه هفتاد و اوایل دهه هشتاد میلادی، محسوب می‌شود. هیچگاه بطور رسمی از هم نپاشید.


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Posted by نيما ساكتي at | Link To This Post ID 157 | Topic : موسیقی(MUSIC)

صد آلبوم برتر راك تاريخ موسيقي معرفي شدند

سايت AVRev.com فهرستي از صد آلبوم برتر راك تاريخ موسيقي را منتشر كرده و آلبوم “نيمه تاريك ماه” گروه “پينك فلويد” صدرنشين اين فهرست شده است.سايت http://www.AVRev.com با معرفي صد آلبوم برتر راك تاريخ موسيقي، براي اهداي مجموعه اين صد آلبوم به بازديدكنندگان اين سايت نيز قرعه كشي به راه انداخته است.


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Posted by نيما ساكتي at | Link To This Post ID 156 | Topic : موسیقی(MUSIC)

نرم افزار آموزشی Music Theory Basics

نرم افزارهای آموزشی معمولاً به دو گروه عمده تقسیم می شوند ؛ گروهی به آموزش مبانی و تئوری موسیقی و گروه دیگر به آموزش تخصیصی سازها مثل آموزش پیانو ، آموزش گیتار و … می پردازند. آموزش صحیح مبانی و تئوری موسیقی، بسیار مهم و با ارزش میباشد چرا که درک درست علم موسیقی و فراگیری نکات اون میتونه در تبحر و سرعت تسلط شخص در ساز مورد علاقه اش کمک زیادی باشه .

آشنایی با نتها ، نت خوانی ، نت نویسی ، آشنایی با صداها ، تشخیص نت نواخته شده توسط یک ساز تنها با گوش دادن به آهنگ ، درک جایگاه هر نت در کالبد یک موسیقی و حسی که ایجاد میکنه ، نواختن یک موسیقی بدون نیاز به نت نویسی تنها با گوش دادن به آن ، … و در نهایت بیان احساسات درون به زبان موسیقی و لذت بردن از آن ؛ همگی بستگی به نحوه آموزش مبانی و تئوری موسیقی دارد . بعد از آموزش صحیح مبانی موسیقی ، فراگیری و تبحر در نواختن سازهای گوناگون به راحتی و سرعت قابل تحصیل میباشد.

با این مقدمه نرم افزاری رو معرفی میکنم با عنوان: Music Theory Basics .

این نرم افزارکه نسخه ی جدید نرم افزار Music Reading میباشد کار Wim Wijnen استاد پیانو در مرکز هنرهای TIEL در کشور هلند میباشد .

با کمک این نرم افزار شما :
با نتها آشنا میشید ،
میتونید به راحتی نت خوانی کنید ،
میتونید نت نویسی کنید ،
قدرت شنوایی و درک موسیقیایی خود را افزایش دهید ،
تنها با گوش دادن نتها رو شناسایی کنید ،
با ریتمها آشنا شوید ،
ملودی بسازید ،
و …

منتها یک مسئله مهم اینکه استاد Wim Wijnen بسیار سخت گیر بوده و اگر در انجام تمریناتی که به شما میدهد ، حتی یک غلط داشته باشید ، شما مردود شده و مجدداً باید اون تمرین رو از ابتدا انجام دهید . با کمی پشت کار و پی گیری تمرینها به سرعت پیشرفت کرده و از ادامه تمرینات لذت خواهید برد. پس از مدتی متوجه میشوید که بجای اینکه به یک موسیقی گوش بدهید ، آنرا میفهمید و لمس میکنید .

برای دانلود برنامه ها میتوانید به این لینک رجوع کنید:

http://www.mtbasics.com

Gold Wave

نرم افزار Gold Wave v5.06این نرم افزار یک ادیتور قوی و مجهز با توانایی تبدیل فرمتهای گوناگون فایلهای صوتی به یکدیگر میباشد.

به کمک این نرم افزار شما میتوانید موسیقی و آهنگهای فایلهای ویدئویی را از آنها جدا کرده و با فرمتهای دلخواه ( Wav , Mp3 , … ) ذخیره کنید


میتوانید افکتهای مختلف ( Fade , Echo , Mix , … ) به موسیقی خود بیافزائید ، حتی شما میتوانید فایل صوتی خود را با فرمت txt ذخیره و بعد بازیابی کنید ( یک جور رمز گذاری کردن ) و دهها امکانات دیگر که کمک زیادی به ما میکنند.
فايل دانلودی:
http://www.goldwaving.com/downloads/gwave426.exe

نرم افزارهای کاربردی گیتار

با توجه به تقاضای دوستان مبنی بر معرفی نرم افزار های کاربردی در گيتار و غيره اينبار سايتی را معرفی ميکنم که فکر کنم شاهکاری در اين زمينه ميباشد که ميتوانيد بيش از ده ها برنامه مفيد را دانلود کنيد

http://www.harmony-central.com/Software/Windows/guitar.html

برنامه Guitar Pro و Tabl Edite

چندی پیش سایتهایی در زمینه نت و تبلچر ارائه شد که اکثر سایتهایی که در زمینه تبلچر فعالیت میکنند از ۲ نرم افزار برای فایلهای خود استفاده مینند فایلهای با پسوند GP4 - GP3 - TEF كه فايلهاي با پسوند GP4 - GP3 با برنامه Guitar Pro و فایلهاي با پسوندTEF با برنامهTablEdit اجرا میشوند

سایتهایی مانند mysongbook.com که سایتی بسیار پرمحتوا در زمینه ارائه آثار راک - جز - فلامنکو - پاپ و… بصورت تبلچر میباشد از برنامه گیتار پرو حمایت میکند و برای استفاده از فایلهای این سایت باید این برنامه را نصب کنید

و یا سایت http://herso.freeservers.com/tabs.html که در زمینه گیتار فلامنکو فعالیت میکند و تبلچر بسیاری از قطعات برجسته فلامنکو از نوازندگان مختلف را در سایت قرار داده است از نرم افزار TablEdit استفاده میکند

که برای دانلود برنامه گیتار پرو :
www.guitar-pro.com
TablEditو برنامه
http://www.tabledit.com/download/downlo_e.shtml

دانلودguitar pro 5

بعید است تا گیتاریسیتی پیدا شود و از برنامه بسیار عالی Guitar pro استفاده نکرده باشد که نسخه جدید ای نرم افزار مدتیست که به بازار آمده که نسبت به برنامه های قدیمیتر از این نرم افزار دچار تغییرات بسیار چه از نظر گرافیکی و چه کار بردی شده است که با توجه به تقاضای بسیاری از دوستان در این قسمت نسخه شماره 5 بهمراه سریال این برنامه برای دانلود در سایت قرار میگیرد.

دانلود

مترونوم مخصوص فلامنکو

یکی از مشکلات هنرجویان فلامنکو نداشتن مترنوم مخصوص جهت تمرین قطعات میباشد. و آنهم مترونومی که بتوان با آن اصول ریتمیک خاص این موسیقی را رعایت نمود که به آن به اصطلاح کمپاس میگویند.

هر چند مترنوم مخصوص آن در ایران ساحته شد اما با توجه به قسمت بالا و محدودیت عرضه استقبالی چندانی نشد.
که با دانلود این مترونوم که اصول ریتمیک دستگاههای فلامنکو در آن رعایت شده است میتوان راه بسیار مفیدی باشد برای اجرای صحیح اجرای قطعات فلامنکو.

دانلود:
Download - Flamecno Mertonom

 

Guitar Speed Trainer

یکی از نرم افزارهای کاربردی در زمینه گیتار Guitar_Speed_Trainerمیباشد که نمونه های تمرینی مفیدی در زمینه بالا بردن سرعت در کنار کیفیت در امر نوازندگی را ارائه میدهد.

از نکات مفید این برنامه ارائه پیشنهادات مفید در زمینه نوازندگی گیتار میباشد همانند نحوه گام و یا نکات بنیادین در نحوه تمرین

و ارائه برنامه تمرینی با سرعت های پیشنهادی برنامه برای بالا بردن سرعت در نوازندگی
دانلود کنید:

Download

Happy Note بازی وآموزش موسیقی

استفاده از برنامه های مختلف توسط نوازندگان و مدرسان گیتار بسیار فراگیر شده است که در حقیقت بسیاری از این برنامه ها کار را برای نوازندگان راحت تر نموده است. در این قسمت 3 برنامه که بصورت بازی طراحی شده است معرفی میشود.در آینده مطالب آموزشی برنامه های حرفه ای برای آهنگسازی و نت نویسی ارائه خواهد شد.

از سری مجموعه برنامه های Happy Note که در این برنامه های بازی هایی بظاهر ساده طراحی شده است که نه تنها جنبه بازی را دارا میباشند بلکه با کمک این برنامه ها میتوانید
1=گوش خود را قویتر سازید
2= آموزش نت خوانی
3=آموزش فواصل و ارزش زمانی نت ها
برای آشنایی بیشتر با این برنامه ها و دانلود به این سایت مراجعه نمایید.

http://www.happynote.com/music/learn.html

 

 

 

 

Posted by نيما ساكتي at | Link To This Post ID 155 | Topic : نرم افزارهای کاریردی گیتار

Filomena Moretti

فیلومنا مورتی یکی از نوازندگان محبوب وشناخته شده در ایران میباشد شاید عمده محبوبیت وی حاصل نمایش کنسرتهای وی از تلویزیون Mezzo فرانسه میباشد . که بسیاری به اشتباه وی را نوازنده ای فرانسوی قلمداد میکنند. مورتی در سال 1973 در شهر Sassariایتالیا بدنیا امد ..


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Posted by نيما ساكتي at | Link To This Post ID 154 | Topic : موسیقی(MUSIC)
جستجو :  

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نتايج يافت شده

توصيه هاي کلي در مورد غذا خوردن

عادت اشتباه در تغذيه

مدیران میانی مقصر کمبودهای دارویی

مواد افزودني يافت شده در يكسري از سوسيس و برگرها (موسوم به ‪ E۱۲۸‬) ، مي‌تواند به سرطان منجر شود.

رژيم غذايي “غربي” كه در آن مصرف گوشت قرمز، نشاسته و قند بالاست، با افزايش سرطان سينه در بين زنان يائسه چيني ارتباط دارد

مشكلات روانشناختي ناشي از ناباروري مي‌تواند يك عامل كمكي در تشديد مشكل افراد نابارور باشد

‪چهل و نه درصد عوامل بيماريزا بين انسان و حيوان مشترك است

خون بند ناف مي‌تواند به توليد انسولين در كودكاني كه به تازگي ديابت نوع يك در آنها تشخيص داده شده است، كمك كند.

دوچرخه سواري به سلامت انسانها در آسيا آسيب مي‌رساند

غذاهاي مملو از آهن، روي، نياسين، تيامين و ويتامين‌هاي ب‪ ۶‬و ب‪ ۱۲‬به تيز نگه داشتن ذهن كمك مي‌كند

رشد سلولهاي جديد مي‌تواند علت تاثير مفيد فعاليت در رفع افسردگي را نشان دهد.

كاهش آسيب اعتياد

بيماري روحي افسردگي براثر عدم شناخت توانايي و محيط بوجود مي‌آيد

احتمال خفگي نوزاد در اثر افتادن از روي صورت وجود دارد

رياضيات رشد مغز مطالعه شد

زنجبيل و نعناع با افزايش خون‌رساني مغزسبب تقويت يادگيري مي‌شود

بيشتر مردم فشارهاي عصبي را مهمترين عامل بيماري قلبي مي‌دانند

كمبود اسيد چرب امگا ۳ در بدن باعث ريزش مو و ضايعات پوستي مي شود .

همواره توانایی قارچ ها برای تولید انبوه پروتئین های ارزشمند مطرح شده است

رزگوجه يا ليم‌گوجه؟ گوجه فرنگي تراريخته با بوي رز و ليمو

بادمجان در درمان بيماري صرع بسيار موثر است

ماده مرجاني براي ترميم بافت استخواني در جراحي‌هاي فك، ارتوپدي و ضربه شناسي

بخش عمده اثر ضد سرطانی سیب به پوست آن مربوط می شود.

عوامل روانشناختي نقش موثري در كنترل درد دارند

استرس ناشي ازقطع دارو علائم بيماري ام.اس را تشديد مي‌كند

چاقي در ناحيه گردن موجب ايست تنفسي هنگام خواب مي‌شود

دانستنيهايي در مورد كرمهاي ضد آفتاب

اختلال خواب راندمان كاري افراد را پنجاه درصد كاهش مي‌دهد

چه كفشي براي پوشيدن مناسب است - كفش استاندارد كدام است

هپاتيت حاد ويروسي
Posted by نيما ساكتي at | Link To This Post ID 149 | Topic : 100مقالات پزشكي(MEDICINE eBOOK)

Mediterranean Sundance

کلیپ تصویری از اجرای قطعه Mediterranean Sundanceتوسط گروه سه نوازی Al DiMeola, Larry Coyell - Biréli Lagrèn

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کلیپ تصویری از اردشیر فرح

کلیپ تصویری از اجرای نوازنده متبحر ایرانی ساکن آمریکا آقای اردشیر فرح بهمراه استرانز . اردشیر نواختن گیتار را از 12 سالگی در ایران شروع کرد.که ابتدا در زمینه موسیقی راک فعاليت مينمود. . چون تمام خانواده اش در رشته راه و ساختمان تحصیل کرده بودند،او هم در آنجا به تحصیل در این رشته پرداخت. و در آنجا بود که بیشتر با موسیقی راک و دنيای نوازندگی گيتار آشنا شد.در حین تحصیل با گروه های راک انگلیسی هم کار می کرد.

بعد از 5 سال به آمریکا رفت ، ابتدا در بوستون و سپس در کالیفرنیا ساکن شد تا اینکه دانشگاه تمام و دوران زندگی حرفه ای فرح، در زمینه موسیقی آغاز شد.

و همراه با استرانز گروه strunz & farah را تشکیل دادند که برگرفته از نام خانوادگی این دو موزیسین بود. حاصل کار این گروه تاکنون14 CD و اجرای حدود 700 کنسرت در تمام آمریکا و اجرای برنامه های متعدد با نوازندگان معروف دنیا در سبک های مختلف جاز ، راک و پاپ است.

کلیپ شماره 1 = Download

کلیپ شماره 2 = Download

 

جنگجو راینهایت

دیدن اجرای تصویری از جنگو راینهارت اسطوره فراموش نشدنی موسیقی و گیتار جز بسیار هیجان آور خواهد بود نوازنده ای که با داشتن مشکلات فیزیکی توانست انقلابی در نوازندگی گیتار جز بوجود آورد. يك ويولونيست و بعداً گيتاريست ، ژان باپتيست راينهارت ( جنگو ) در يك كمپ كولي در نزديكي پاريس بزرگ شد جايي كه او ذات كولي را در موسيقي خويش هضم كرد . آتش خانمان سوز كاروان در سال 1928 دست چپ وي را به شدت سوزاند و او را از استفاده از دو انگشت دست چپش 3 و 4 محروم كرد !

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کلیپ تصویری از John Mc Laughlin

با توجه به درخواست بسیاری از دوستان مبنی بر ارائه کلیپ های تصویری از اجرای قطعات جدید از نوازندگان برجسته این سبک این بار مجموعه غنی از ویدیو کلیپ های تصویری از نوازنده برجسته گیتار جز John Mc Laughlin به همراه اجراهایی با پاکو دلوسیا نوازنده شهیر فلامنکو و اجرا با سایر نوازندگان .

www.italway.it/morrone/WBTG-videos.htm

 

آموزش گيتار توسط جو ستريانی

آموزش گيتار توسط جو ستريانی: در اين قسمت ميتوانيد مجموعه ای از آموزشهای جو ستريانی را بصورت نت و تبلچر مورد استفاده قرار داده و همچنين کليپ های تصويری از اين نوازنده را نيز دانلود کنيد


قسمت آموزشی:
lessons

کلیپ:

videos

 

 

 

 

 

Posted by نيما ساكتي at | Link To This Post ID 152 | Topic : تصویری راک ,جز و بلوز
 

 

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پروتز

پرتوشناسی

پاندمی

پروتئین P-gp

پاراتیون

پاتوژن

Posted by نيما ساكتي at | Link To This Post ID 151 | Topic : 100مقالات پزشكي(MEDICINE eBOOK)
سندرم هپاتورنال

هپاتيت در بيماران دياليزي و پيوند كليه

واكسيناسيون هپاتيت B

پياده روي موجب افزايش توده استخواني ران و کاهش احتمالي شکستگي مي‌شود

مردان در آستانه پدر شدن دچار علايم بارداري مي‌شوند!

مصرف آبزيان در پيشگيري ازمشكلات گوارشي و بيماريهاي قلبي موثر است

طراحي دکوراسيون محل کار در سلامت افراد تاثيرگذار است

سلول مادر عامل

مصرف آبزيان موجب تقويت حافظه و يادگيري كودكان مي‌شود

خطر داره، پسر!

پیشرفت در درمان بیماری خواب و بمب گوگلی

دكتر هرمز شمس، رئيس انجمن چشم پزشكان مي گويد

عينك هاي آفتابي

عينک

کالبدشناسی انسان

کمون

کنسانتره امولسیفیابل

کنترل بیماری

چشم‌پزشکی

پیرتروم

پیشگیری ثانویه

پیشگیری ثالثیه

پیشگیری اولیه

پیشابراه

پزشکی سنتی چینی

پزشکی کودکان

پزشکی

پلاسما

پودر وتابل

پروپرانولول

Posted by نيما ساكتي at | Link To This Post ID 150 | Topic : 100مقالات پزشكي(MEDICINE eBOOK)

Rasgueados are for everyone

By Nitin Arora

Ebook

This book is devoted entirely to rasgueado technique. With highly detailed explanations of the sixteen basic rasgueado patterns, the reader can learn the what, when, and how of the fingers through step-by-step instructions and Visual Dictionary (step-by-step photos of all the basic patterns).

 

geocities.com/nitaro74

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Posted by نيما ساكتي at | Link To This Post ID 148 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)
What flamenco is NOT Ebook

An in depth look at the misconceptions about flamenco. In the eyes of the uninformed general public, flamenco could mean just about anything.

 

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Posted by نيما ساكتي at | Link To This Post ID 147 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)
Rasgueado Secrets Ebook A detailed technical manual explaining how to produce clean and strong rasgueados. The three examples shown have detailed explanations, photos and links to the demonstration videos.
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Posted by نيما ساكتي at | Link To This Post ID 146 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)

Flamenco style charts and family tree

By Sal Bonavita

Flamenco styles  Ebook This contains reference charts and diagrams relating to flamenco styles (Palos) and their family groupings.
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Posted by نيما ساكتي at | Link To This Post ID 145 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)
The elusive flamenco spirit

A look at the many faces of the elusive flamenco spirit.

Variously defined as ghost, specter or goblin, the word 'Duende' could also be interpreted as the power to attract through personal magnetism and charm. In flamenco, this word is used to describe the trance like fixation, or haunting feeling one may experience while enjoying a flamenco performance.

 

Duende is an inner spirit, which is released as a result of a performer's intense emotional involvement with the music, song and dance. If you experience a shiver of recognition, even for an instant, it means the duende has successfully transferred a lifetime's worth of joy and pain from the performer to you.

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Posted by نيما ساكتي at | Link To This Post ID 144 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)
 

 

The Moors

By Sal Bonavita

The Moors Who were they? Who were they? They must have been somebody. They were in Spain for nearly 800 years and finally got kicked out in the same year Columbus sailed the ocean blue.
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Posted by نيما ساكتي at | Link To This Post ID 143 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)

Rasgueado secrets

By Sal Bonavita

Rasgueado Secrets Ebook A detailed technical manual explaining how to produce clean and strong rasgueados. The three examples shown have detailed explanations, photos and links to the demonstration videos.
Download  

 

Posted by نيما ساكتي at | Link To This Post ID 142 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)
Flamenco dictionary
Posted by نيما ساكتي at | Link To This Post ID 141 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)
Learn flamenco tremolo
Posted by نيما ساكتي at | Link To This Post ID 140 | Topic : ُُكتابخانه الكترونيك موسيقي(EBOOK)

افزایش اشتها در مبتلایان به ایدز

 

 

 

 

از آنجایى كه در مبتلایان به ایدز، اختلال در حس چشایى وجود دارد ، منجر به كاهش اشتها و در نتیجه لاغرى مفرط در آنها مى شود. بنابراین برای بهبود وضعیت اشتها ،در زیر به برخى مواد غذایى اشتها آور اشاره مى كنیم:

 

 


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Posted by نيما ساكتي at | Link To This Post ID 138 | Topic : مقالات فارسی
مبانی بنیادی در موسیقی

دانشی که یک نوازنده بعنوان موزیسین باید بدان آگاه باشد شناخت از موسیقی و اجزای آن میباشد نه تنها اشراف به نت ها و قواعد تئوریک بلکه توجه کافی به فلسفه هنر و موسیقی - تاریخ موسیقی و شناخت دوره های موسیقی و تاثیر سایر هنرها بر موسیقی و غیره میباشد. که سعی میشود طی مباحث پیوسته به هر یک از آنها پرداخته شود. اما مبانی موسیقی ومباحث مربوط به آن

مسلما با وجود کتابهای بسیار مفید در این زمینه لزومی نیست تا این مطالب در سایت قرار گیرد اما باتوجه به اینکه در آموزش گیتار یکی از مراحل آموزش شناخت تئوری موسیقیست سعی شده است تا با گردآوری و جمع بندی از کتابهای مختلف به هدف نهایی مطلوبی برسیم.


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Posted by نيما ساكتي at | Link To This Post ID 137 | Topic : تئوری موسیقی

تئوری پایه ای موسیقی

تئوری موسیقی چیست؟ دانشی که به قواعد نوشتن نت‌های موسیقی و مقولات مرتبط با آن می‌پردازد، تئوری موسیقی نام دارد.

موسیقی

موسیقی، به هر نوا و صدایی گفته می‌شود که شنیدنی و خوش‌آیند باشد و انسان یا موجودات زنده را دچار تحولی کند. واژه موسیقی از واژه ای یونانی و گرفته شده از کلمه Mousika و مشتق از کلمه Muse می باشد که نام رب النوع حافظ شعر و ادب و موسیقی یونان باستان می باشد. موسیقی را هنر بیان احساسات به وسیله آواها گفته اند که مهمترین عوامل آن صدا و ریتم هستند و همچنین دانش ترکیب صداها به گونه ای که خوش آیند باشد و سبب انبساط و انقلاب روان گردد نامیده می شود؛ پیشینیان موسیقی را چنین تعریف کرده اند: معرفت الحان و آنچه التیام الحان بدان بود و بدان کامل شود.

ارسطو موسیقی را یکی از شاخه های ریاضی می دانسته و فیلسوفان اسلامی نیز این نظر را پذیرفته اند همانند ابو علی سینا که در بخش ریاضی کتاب شفا از موسیقی نام برده است ولی از آنجا که همه ویژگی های موسیقی مانند ریاضی مسلم و غیرقابل تغییر نیست، بلکه ذوق وقریحه سازنده و نوازنده هم در آن دخالت تام دارد، آن را هنر نیز می دانند. در هر صورت موسیقی امروز دانش و هنری گسترده است که دارای بخش های گوناگون و تخصصی می باشد

نت

گوییدو دآرتسو (1050-990، Guido d’Arezzo)، کشیشی فرانسوی، ساکن ایتالیای قرن 11 میلادی، برای نخستین بار نام این نت‌ها را بر اساس سروده‌ای مشهور به سرود سن ژان که گویا خود برایش آهنگی ساخته بود انتخاب کرد:

Ut queant laxis resonare fibris Mira gestorum famuli tuorum Solve poluti labireatum Sancte Johannes.

در این دوران موسیقی شش‌هجایی بود و در سده‌های پس از آن بود که «سی» بر آن افزوده شد و هجای «دو» جایگزین «اوت» شد.

نُت در موسیقی به دو معنی بکار می‌رود: یکی به معنی واحد صدائی با فرکانس ثابت که نامی بر آن گذاشته شده و دیگری به معنی نمایش یا نشانه نوشتاری هر یک از این صداها.

در معنی اول نت‌ها هفت نام برای نوشتن اصوات موسیقایی هستند. در ایران به پیروی از فرانسه و ایتالیا نت‌ها به این صورت نام گذاری می‌شوند: دو-ر-می-فا-سل-لا-سی (do, re, mi, fa, sol, la, si). در روش نام‌گذاری الفبایی که در کشورهای انگلیسی و آلمانی زبان رایج بوده است نت‌ها به ترتیب “A, B, C, D, E, F, G” نام می‌گیرند، که نت A در این روش برابر با نت «لا» (la) در روش قبلی است.

نامگذاری هجایی:Do Re mi Fa Sol La Si

نامگذاری الفبایی:C D E F G A B

در معنی دوم، برای مکتوب کردن اصوات موسیقی، این صداها را طبق قواعد خاصی بین یا روی پنچ خط افقی می‌نویسند که به نام خطوط حامل شناخته می‌شوند. خطوط حامل از پایین به بالا شمرده می‌شوند، به این معنی که نتی که روی خط پایین‌تر نوشته شود، صدایی بم‌تر از نتی دارد که بر روی خط بالاتر نوشته شده است. به این ترتیب نام نت از روی جائی‌که روی خط‌های حامل قراردارد مشخص می‌شود. دیگر مشخصات نت مانند طول آن (مدت زمان امتداد یافتن آن صدا) و غیره را نیز با شکل‌های قراردادی که برای نت طرح شده نمایش می‌دهند. نت‌های متوالی را از چپ به راست می‌نویسند.

در شکل زیرنت‌ها به صورت دایره‌های کوچکی (بعد از نشانه کلید سل ) به‌ترتیب از چپ به راست روی پنج خط حامل نوشته شده‌اند.

۲.کلیدها:

یکی دیگر از راههای نشان دادن نت ها استفاده از کلید هایی با فواصل (زیر و بمی) متفاوت میباشد .

انواع کلید ها :
كليد :
علامتي است كه سمت چپ خطوط حامل قرار مي گيرد و نام و موقعيت نت را روي خطوط حامل مشخص مي كند

کلید(clef): نت ها به خودی خود شکل مشخصی ندارند که از آن طریق بتوان نام نت را حدس زد ، این کار (شناختن نام نت ها بر روی حامل ) با کمک کلید صورت می گیرد .

سه نوع کلید با نام های کلید سل ، فا و دو وجود دارد که البته معمولا از کلید سل استفاده می شود .

کلید سل همیشه روی خط دوم حامل قرار می گیرد . بنابر این نتی که روی خط دوم قرار بگیرد نت سل خواهد بود . بر خلاف کلید سل کلید های فا و دو در بیش از یک محل روی حامل قرار می گیرند ومثل کلید سل نام خود را به همان خط و نت روی آن می دهند .

کلید سل:

در ساز گيتار تنها كليد سل است كه كاربرد دارد

خطوط حامل
زبان موسیقی نتها هستند که بدون خطوط حامل معنایی ندارند .خطوط حامل 5 خط موازی افقی هستند که نت ها می تونند روی این خط ها(5 تا)و بین آنها(4 تا)و بالا و پایین آنها(2 تا)نوشته شوند که جمعا 11 نت می توانند در خطوط حامل نوشته شوند.و اگر نیاز به بیش از این نت ها باشد از خطوط حامل تکمیلی استفاده می شود.خواندن نتها از روی خطوط حامل به این گونه است که ابتدا باید کلید سل یا فا یا دو بر روی ان مشخص باشد.برای مثال کلید سل بر روی خط دوم از پایین قرار میگیرد ولی کلیدهای فا و دو جای مشخصی ندارند.بنابراین هر نتی که روی خط دوم قرار بگیرد سل خوانده می‌شود .با مشخص شدن نت سل نت های دیگر نیز با توجه به زیر وبمیشان نسبت به نت سل مشخص می‌شوند.که اگر به بالا و جلو برویم نت ها زیرتر(سل-لا-سی-دو-ر-………)واگر به پایین و عقب برگردیم نت ها بم تر(فا-می-ر-دو-سی-……….)می شوند

خط های تکمیلی : همانطور که گفته شد روی حامل تنها 11 نت جای می گیرد ، که نسبت به تعداد کل نت های موسیقی (بیش از 60 نت) رقم بسیار ناچیزی است . برای رفع این کمبود ، در زیر و بالای حامل ،هر جا و هر زمان که نیاز باشد خط های کوتاه به طور موقت می گذارند و به کمک آنها بر کاربرد حامل و وسعت نت نویسی روی آن می افزایند .

حامل مضاعف : برخی از سازهای موسیقی ( مانند ارگ کلیسا و پیانو ) دارای وسعتی بسیار گسترده اند . در این نوع سازها از دو خط حامل استفاده می شود که معمولا نت هایی که روی حامل پایین نوشته می شود با دست چپ و نت های روی حامل بالا با دست راست اجرا میشوند کلید فا نیز معمولا برای دست چپ و صداهای بم و پایین رونده استفاده می شود .

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Posted by نيما ساكتي at | Link To This Post ID 136 | Topic : تئوری موسیقی

خواص صداها


فراوانی و ارتفاع :دیاپازنها و سایر آلات مرتعش از لحاظ عده موجهای کاملی که در هر ثانیه ایجاد می‌کنند باهم اختلاف دارند. مثلا می‌گویند یک دیاپازن 256 سیکل در ثانیه فراوانی دارد و دیگری 1024 سیکل هر چه فراوانی موجها زیادتر شود، آثار امواج در روی صفحه موج نگار به هم نزدیکتر می‌شود. زیر و بمی صوت به فراوانی بسته است، هر چه موجها زیادتر شوند صوت زیرتر و هر چه کمتر شوند صوت بمتر می‌شوند.

مادام که فراوانی امواج بالاتر از آستانه حس است این نسبت بر قرار است. زیر و بمی با شدت صوت نیز ارتباط پیدا می‌کند یعنی از حد معینی که بگذریم صوت بم هر چه شدیدتر شود بمتر و صوت زیر هر چه شدیدتر شود زیرتر می‌شود.

شدت و دامنه امواج صوت
امواج صوت در دامنه نیز باهم تفاوت دارند. در روی موج نگار هر چه عقربه موج نگار بیشتر از وسط صفحه منحرف شود و بیشتر به بالا و پایین برود گوئیم دامنه داری صدا بیشتر است امواج دیاپازنها اول دامنه‌های بلندتر دارند و به تدریج کوتاهتر می‌شوند تا بکلی متوقف می‌گردند یعنی صوت قطع می‌شود.

دامنه ارتعاشات ، شدت محرک و نیروئی را که در ایجاد آن بکار برده شده است نشان می‌دهد هر چه دامنه ارتعاشات بیشتر باشد صوت به گوش ما بلندتر می‌آید، اما بلندی صدا به فراوانی موج نیز مربوط می‌شود. فراوانی خیلی کم و زیاد ، یعنی نزدیک به مرز شنوایی ، باید بلندی بیشتری داشته باشد تا شنیده شود.

واحد اندازه گیری شدت صدا دسی ‌بل است و معمولا می‌گویند صدایی فلان قدر دسیبل از مرز شنوایی بالاتر است، یک بل ده برابر شدتی است که محرک باید داشته باشد تا در مرز شنوایی قرار گیرد و ده بل صد برابر این شدت و سه بل هزار برابر این شدت است، پس بل لگاریتمی با پایه ده است و نسبت شدت صوت مورد بحث را با شدت آستانه احساس صوت نشان می‌دهد. دسی بل یک دهم بل است..

طنین و پیچیدگی امواج صوت
تجزیه امواج صوت بخصوص امواجی که پیچیدگی زیاد دارند نیازمند دستگاهی دقیقتر و حساس از موج نگاری است که دیدیم دستگاهی که برای این منظور بکار می‌رود موج نگار با اشعه کاتود است. چنانکه دیدیم دیاپازن ساده تراکم و انبساطی در هوا ایجاد می‌کند که بصورت منحنی ساده‌ای ثبت می‌شود.

دو دیاپازن که فراوانی آنها مختلف است اگر باهم مرتعش شوند موج پیچیده‌ای ایجاد می‌کنند که روی موج فرودی آنها را می‌پوشاند. موج صوتی پیچیده‌تری را می‌توان با مرتعش کردن سیم کشیده‌ای بوجود آورد این سیم زیر و بمی خاص ایجاد می‌کند که بصورت اصلی معروف است، اما آن سیم در عین حال در همه طول خود و در قطعات دیگر نیز ارتعاشات خاصی دارد، اینها را ارتعاشات پاره‌ها خوانند. هر پاره زیر و بمی خاص خود دارد که هارمونیک (یا اورتون) خوانده می‌شود.

اورتونها
وقتی ضربتی به سیمی می‌نوازیم صوت بلند پییچیده‌ای به گوش می‌رسد. اما اگر آن سیم را با موی نرمی در وسط مرتعش کنیم صوت ساده‌ای خیلی زیرتر از آهنگ اصلی از آن بر می‌خیزد. اگر فراوانی آهنگ اصلی 252 سیکل در ثانیه باشد، فراوانی آهنگ پاره‌ای 512 سیکل در ثانیه است، آهنگی که شنیده می‌شود، اورتون اول خوانده می‌شود.

حال اگر سیم را در یک سوم طولش مرتعش کنیم، صوتی زیرتر از صوت پیش بگوش می‌رسد، فراوانی موج این صوت سه برابر فراوانی موج صوت اصلی یعنی 768 سیکل در ثانیه خواهد بود، این را اورتون دوم خوانند. به همین ترتیب ممکن است سیم را در یک چهارم طول و یک پنجم و یک ششم و یک هفتم و …
مرتعش کنیم.

در هر قدم صوت سیم زیرتر می‌شود، هر چه ارتعاش روی قطعات کوتاهتر سیم باشد دامنه موجها کو تاهتر می‌شود و بلندی صوت به مرور کم می‌شود. آلات موسیقی پیچیده ، گذشته از صوت اصلی ، اورتونهای بسیار از خود بیرون می‌دهند، الگوی تراکم و انبساط هوا چنان پیچیده است که اگر بر موج نگاری ثبت شود چشم نمی‌تواند آنها را از هم تفکیک کند و باید به وسائل ریاضی و الکتریکی آنها را تجزیه کرد.


رزونانس
آلات موسیقی مختلف نه تنها ارتعاشات پاره‌ای مختلف ایجاد می‌کنند بلکه خواص رزونانس آنها نیز مختلف است، به عبارت دیگر بعضی اورتونها را تشدید و بعضی را مخفف می‌کنند. یک آلت موسیقی ممکن است اورتونهای بم را تشدید کند و دیگری اورتونهای زیر را به همین سان.

اصل رزونانس با آزمایش ساده‌ای روشن می‌شود دیاپازنی را نزدیک پیانو مرتعش کنید. فرض کنید که آهنگی که تولید می‌کند c میانه باشد (256 سیکل)، سیمهای پیانو در اثر این ارتعاش مرتعش می‌شود و حداکثر ارتعاش c میانه خواهد بود. ممکن است در آزمایشگاه دیاپازنهایی را دیده باشید که روی جعبه‌ای سوار است (جعبه رزناتور).

اینها وقتی از جعبه جدا شوند صوتشان ضعیف می‌شود، این جعبه‌ها چنان ساخته شده‌اند که هوای درون آنها با ارتعاش دیاپازنها مرتعش می‌شود.

پیانو و ویولون و ساکسوفون چنانکه ساخته شده‌اند که برای بعضی از پاره‌ها رزنانس فراهم می‌کنند. برای دیدن اینکه چگونه اختلاف در اورتونها ، آهنگهای آلات مختلف موسیقی را از هم مشخص می‌کند، می‌توان از صافی صوت استفاده کرد. این صافیها پیچیدگی صوت را کم می‌کنند یعنی ارتعاشات پاره‌ها و در نتیجه اورتونها را می‌گیرند و آهنگ اصلی را به گوش می‌رسانند.

هر چه اور تونها بیشتر گرفته شوند تفاوت طنین نامحسوستر می‌شوند. اگر نت c میانه در روی پیانو و ویولون سل و شیپور نواخته شود، هر یک طنین مخصوص خود را خواهند داشت. اما وقتی فقط ارتعاش اصلی به گوش برسد و اورتونها حذف شود، آهنگ همه آلات موسیقی به هم شبیه می‌شود. هر چه اورتونها بیشتر به گوش برسند آهنگ خاص هر آلت موسیقی بهتر تشخیص داده می‌شود.

موسیقی را از راه شناخت چهار ویژگی بنیادی صداهای موسیقیایی - یعنی :زیر و بم (یا ارتفاع صوت )- دینامیک (شدت صوت )- رنگ صوتی و کشش (صوت تداوم صوت) از صداهای دیگر متمایز می سازیم (غیر موسیقیای) .

ارتفاع صوت:
زیر یا بم بودن آن نسبت به دیگر اصوات است . بی تردید متوجه شده اید که اغلب مردان با صدایی بم تر از زنان و کودکان صحبت می کنند و آواز می خوانند - زیر و بمی صداها با فرکانس نوسانهای آن تعیین می شود - هر چه نوسان تند تر باشد صدا زیرتر و هر چه کند تر باشد صدا بم تر خواهد بود . ب

ه طور عام هر چه شیء نوسان کننده کوچکتر باشد نوسانی تند تر خواهد داشت و صدای حاصل از آن زیرتر خواهد بود . از میان دو سیم که درازی متفاوتی دارند _وکشیدگی و قطرشان یکسان است )سیم کوتاه تر با زخمه زدن صدایی زیرتر ایجاد می کند . سیم های به نسبت کوتاه ویلون - صداهای زیرتر از سیم های طویل کنترباس پدید می آورند .

صدایی که دارای زیر و بم یا ارتفاع معین باشد - “صدای موسیقیای” نامیده می شود .
تفاوت زیر و بمی یا ارتفاع دو صدای موسیقیای “فاصله” نامیده می شود .
فاصله میان بم ترین و زیرترین صداهایی که یک آوازخوان یا ساز می تواند اجرا کند “وسعت صوتیی” یا به طور ساده “وسعت” نامیده می شود .

ارتفاع در موسیقی به معنای درکی است که گوش شنونده از فرکانس یا میزان زیر و بم بودن نت‌ها دارد.
چون گوش انسان نمی‌تواند فرکانس نت‌ها را به دقت وسائل اندازه‌گیری تشخیص دهد، ارتفاع با فرکانس فرق دارد. مثلاً نت «لا» صدائی خالص است با فرکانس ۴۴۰ هرتز ولی اگر دستگاهی یا سازی صدائی با فرکانس ۴۴۵ هرتز تولید کند گوش انسان این تفاوت فرکانس را درک نمی‌کند و آن را نیز نت لا می‌پندارد.

بايد اين نکته را يادآور شد که صداي انسان مانند ساز و حتي بهتر از آن قادر است نتهاي موسيقي را توليد نمايد و اين ساز آوازي کاملترين آلت موسيقي طبيعي است و بهتر از هر ساز ديگري مي‌تواند احساس‌هاي دروني را نشان دهد. لذا در علم موسيقي آواز زن و مرد را از حيث زير و بمي به شش قسمت کلي تقسيم کرده‌اند:
1. سوپرانو که صداي زير و ظريف است
2. متسو سوپرانو که صداي متوسط زن است
3. کنترالتو که صداي بم زن است
4. تنور که صداي عادي مرد است
5. باريتون که صداي بم مرد است
6. باس که بم‌ترين صداي مرد است

دینامیک:
میزان شدت صدا در موسیقی دینامیک نامیده می شود . به طور مثال هر قدر سیم گیتار شدید تر نواخته شود صدای پدید آمده قوی تر خواهد بود - تعیین دینامیک نیز مانند بسیاری از عناصر موسیقی مطلق نیست . هر صدا نسبت به صدای مجاورش دینامیکی ملایم یا قوی دارد .

رنگ صوتی :
حتی هنگامی که فلوت صدایی واحد را با دینامیکی یکسان بنوازند نیز صدایشان را از یکدیگر تشخیص می دهیم . کیفیتی که صدای آن ها را از هم متمایز می کند “رنگ صوتی” نامیده می شود .

نوشته:نیما ساکتی

 

Posted by نيما ساكتي at | Link To This Post ID 135 | Topic : تئوری موسیقی

تئوری موسقی ـ کشش ها ۱

( Note Duration) کشش نتها :دیرند یا کشش یعنی زمانی که هر صدای موسیقیای ادامه می یابد(مدت زمان نواختن نت را کشش نت میگوییم) . روشن است که یک آهنگ موسیقی از صداهایی تشکیل شده که غالبا ارزش های متفاوتی زمانی دارند - یعنی بعضی کوتاهتر و بعضی کشیده ترند

( نت گرد:
این نت در بین مابقی علایم بیشترین مدت زمان کشش را دارد و آن را به عنوان نت واحد مینامیم، این زمان معادل 4 ضرب است مثلا سیم اول را گیتار را بصدا در میآوریم و 4 ثانیه میگذاریم به ارتعاش ادامه دهد. (در ایتجا هر ضرب را برای مثال یک ثانبه محاسبه کرده ایم)

نت سفيد :
مقدار کشش زمانی نت سفید برابر است با 2/1 ارزش زمانی نت گرد . معادل 2 ضرب .

نت سياه:
مقدار کشش زمانی نت سیاه برابر است با 4/1 ارزش زمانی نت گرد . معادل 1 ضرب
به این ترتیب نت سیاه معادل یک چهارم نت گرد و یک دوم نت سفید است

نت چنگ :
اين نت از لحاظ زماني2/ 1 واحد كشش زماني كه همان نت سیاه است مي باشد.

نت دو لا چنگ :
این نت دارای 2 پرچم و معادل 16/1 نت گرد و 4/1 نت سیاه (ضرب ) است .

به همین ترتیب نتهای سه لا چنگ و چهارلا چنگ نیز وجود دارند که به ترتیب 32/1 و 64/1 نت گرد هستند
این به این معنی است که هر 64 نت چهارلا چنگ معادل 1 نت گرد است

پس متوجه شدیم:

هر 2 نت سفید - هر چهار نت سیاه - هر 8 نت چنگ - هر 16 نت دولاچنگ - هر 32 نت سه لاچنگ و هر 64 نت چهارلاچنگ معادل یک نت گرد میباشد. و به همین طریق نیز میتوان سایر کشش ها را معدل سازی نمود مثلا هر دو نت چنگ معادل یک نت سیاه میباشد و یا 2 نت دولاچنگ معادل یک نت چنگ میباشد و غیره.
برای درک این موضوع به این هرم توجه کنید:

(Flagپرچم (
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براي كشيدن دم نت هرگاه نت از خط سوم بالاتر بود دم آن را به سمت پايين مي كشيم هنگامي كه پايين تر از خط سوم بود به سمت بالا مي كشيم

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Posted by نيما ساكتي at | Link To This Post ID 134 | Topic : تئوری موسیقی

اموزش گیتار قسمت ۲

در زمینه آموزش گیتار درخواستهای بسیاری شده است که در طی مطالب مختلف نکات آموزشی مفیدی در سایت قرار گرفت اما از این پس سعی میشود طی مطالب پی در پی از نکات ابتدایی تا پیشرفته نوازندگی مورد توجه قرار گیرد . هر چند بیان این مطالب یهیچ عنوان آموزش کامل نیست بلکه همواره حضور استادی با تجربه و آشنا به تدریس همراه با شیوه های جدید الزامی میباشد و این مطالب تنها جنبه کمک اموزشی دارد.

اما منابع مورد استفاده در زمینه آموزش گیتار در سیکهای کلاسیک - فلامنکو -و در اینده جز و راک
در زمینه کلاسیک از بهترین متد های اموزشی روز جهان استفاده میشود همراه با نمونه های تصویری چون آموزش گیتار کلاسیک اسکات تنانت - فردریک هند - شارون آیزبین و …
در فلامنکو متد های اموزشی خوان مارتین - اسکار هررو - خراردو نونز - توماتیتو و غیره
در مباحث تکنیک های دست چپ و راست بسیاری از این مباحث میان دو سبک فلامنکو و کلاسیک مشترک سعی میشود از بهترین و مفید ترین منابع استفاده شود.

و همچنین تجربیات شخصی خود بنده که طی این سالها از اساتید مختلف و بالاخص مستر کلاس ها بدست آورده ام استفاده خواهد شد.

و مسلما سعی میشود تا تفکرات شخصی و ایده های شخصی از نوشته حذف شود
و بهیچ عنوان در آموزش تکنیک ها مثال های بی پایه و بی ارزش علمی هچون زیبا تر نواختن فلان تکنیک نسب به نوازنده ای دیگر بیان نمیشود
که متاسفانه در وبلاگ ها و سایت ها مختلف در این زمینه مطالب نادرست بسیاری مشاهده میشود.

در هر حال امید است با ارائه این مطالب پاسخگوی سوالات خوانندگان سایت باشیم .

 

نوشته :نیماساکتی

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ارمیک

نام آرميک برای همه نوازندگان گيتار و بسياري از مردم آشناست چه آن زمان که نوای گيتار او روح بخش و غنای آثار خوانندگانی چون شهيار قنبری بود و چه زمانی که همه دنيا او را بعنوان گيتاريستی مطرح با سبکی مخصوص به او شناختند.


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                                    Jalap

 

 

  • Common name:  Jalap
  • Source: www.glamor.tk
  • CONDUCTION: www.prowl.blogfa.com
  • Writer: nima saketi
  • Email: prowl.nima@gmail.com
  • Botanical Source:  Jalap has a fleshy, tuberous, pyriform root, with numerous roundish tubercles. The stems are numerous, smooth, brownish, very slightly rough, with a tendency to twist, twinning about surrounding bodies. The leaves are long petioled, the first hastate, the succeeding ones cordate, acuminate, mucronate, smooth, deeply incised at base, and conspicuously veined beneath. Peduncles axillary, 2-flowered, rarely 3, twisted, as long as the petioles. Calyx has no bracts; composed of 5 smooth, obtuse, mucronate sepals. The corolla is funnel-shaped, purple, with a long, somewhat clavate tube, and an undulated limb, with 5 plaits. Stamens 5; filaments smooth, unequal, and longer than the corolla tube; anthers white, oblong-linear, and projecting. Ovary slender, and 2-celled; stigma simple, capitate, and deeply furrowed. Capsule 2-celled; cells 2-seeded; seeds unknown.
  • History:  It is only within comparatively recent years that any certainty has existed in relation to the plant from which jalap root is obtained. It was first spoken of in 1609, as Bryonia mechoacana nigricans, then it was regarded by Ray as Convolvulus Americanus jalapium dictus, after which Tournefort, being deceived by persons who asserted that they had seen the plant growing, referred it to a species of Mirabilis. Balfour placed it as the Exogonium purga, and Linnaeus named it Convolvulus jalapa, and thus much difference of opinion existed until, in 1827, when Dr. J. R. Coxe, of Philadelphia, succeeded in obtaining perfect flowers from roots of the true plant furnished to him from their native soils, and thus first made its true character known to the scientific world.

The name of Ipomoea purga was bestowed upon the plant by Wenderoth and Hayne, but as the authorities of this country have, undoubtedly, the first claim, it may be viewed as fixed that I. jalapa, the name originally given to it by Nuttall, is the official plant.

The jalap plant is found in a deep, rich, vegetable soil, at an elevation of nearly 6000 feet above the level of the sea, growing in Mexico, near Chicanquiaco and Xalapa, from which last named place it is usually exported, and from which it has also obtained its name. It is generally imported in bags, containing 100 or 200 pounds. The root is the official part, and is gathered in all seasons, but principally in March and April, when the young shoots are appearing. The plant may be cultivated in the southern parts of the United States.

In 1866, Dr. D. Hanbury planted a root or tuber of Jalap in a garden, near London, and obtained promising results. It is now successfully grown in Jamaica and in India, especially in the Nilgherry hills of that country.

According to Warden (1887), the jalap tubers of India are not of first quality. Jalap is a very variable drug, much of it being of an inferior quality. The best kind is that known as the Vera Cruz variety. Several related, and often inferior drugs, e. g., Tampico jalap, have appeared on the market.

  • Description: 

When fresh, the root is black externally, white and milky within, and varies in size according to its age, from that of a walnut to that of a moderate-sized turnip. It is dried in net bags over the fire, sometimes whole, and sometimes in sections. It is often preyed upon by insects which, however, leave its active part untouched, rendering it consequently more energetic. Jalap thus preyed upon is used for procuring the resin, but should not be given internally, except in much smaller doses than for the ordinary root.

Jalap is rather difficult to polvorize, but if triturated with cream of tartar, sugar of milk, or other hard salt, the process of polvorization is facilitated, and the powder rendered much finer. When in powder, the color is a pale grayish-brown, and when in contact with the mucus membrane of the air-tube, causes coughing and sternutation, with an increased discharge of saliva. Its solvents are water, alcohol, or spirits. Water takes up a small portion of its cathartic principle, but considerable of an amylaceous and mucilaginous extractive matter. Alcohol dissolves the resin, on which its cathartic virtues depend. Ether only partially dissolves it. Diluted alcohol completely extracts its active properties.

  • Action, Medical Uses, and Dosage:  Jalap is an irritant and cathartic, operating energetically, occasioning profuse liquid stools with griping, and sometimes sickness at stomach, or even vomiting. Large doses produce violent hypercatharsis, sometimes terminating fatally.

When applied to a wound, it is said to induce purgation. Notwithstanding its activity, it is a safe and convenient purgative, much in use among the profession, and is useful in all cases where it is desirable to produce an energetic influence on the bowels, or to obtain large evacuations.

If intestinal inflammations are present it should not be used.

United with the bitartrate of potassium, its hydragogue properties are much increased, and thus it proves beneficial in dropsies, as well as in some forms of scrofula. Jalap, however, is suitable for excitable, active conditions, and may be used where a cooling effect is desired, as when it is necessary to evacuate the bowels in febrile disorders.

Inflammatory conditions of the biliary apparatus are exceptions to the rule that it should not be used in gastro-intestinal inflammations. When the rectum is impacted with a hard, fecal mass, the expulsion of the latter is facilitated by the purgative action of jalap, which greatly augments the intestinal secretions; all cases of constipation, due to dryness of the mucus membranes, through inactivity of the intestinal glands, are relieved by jalap. The dose for this latter purpose may be 5 grains in the morning, repeated for several days. When a stimulating laxative can not be used because of hemorrhoids, jalap may be employed, and it is likewise efficient as a derivative in cerebral disorders.

It is stated that the aqueous extract of jalap, the root having been previously exhausted of its resin by alcohol, will exert no cathartic influence, but will operate as a powerful diuretic, but I have not been able to procure this effect, though having made a trial in several cases (King). Three grains of jalap, taken an hour before each meal, act as a slight nauseant, destroying a desire for food among persons who are apt to eat too freely. If jalap is digested in ether, its nauseous taste and smell will be wholly removed without lessening its cathartic power. A biscuit is sometimes made for those to whom it is extremely nauseous and disagreeable; 5 drachms of jalap, 30 of sugar, and 4 ounces of flour, are made into 15 biscuits after the usual mode; 1 biscuit is a dose. The tendency of jalap to gripe and nauseate, may be obviated by adding to the dose 1 or 2 grains of camphor, or 3 grains of cloves. The dose of powdered jalap is from 10 to 30 grains (the aqueous extract ought not to be used, except as a diuretic)of the tincture, from 1 to 4 fluid drachms; the resin, or alcoholic extract, is given in from 2 to 8-grain doses, being usually rubbed up with sugar, or in emulsion, for the purpose of lessening its disposition to produce painful irritation of the intestinal mucus membrane.

As a hydragogue, 2 drachms of the bitartrate of potassium are added to 10 or 30 grains of polvorize jalap. Convolvulin (rhodeoretin) purges violently in 3 or 4-grain doses, and appears to be the active principle of jalap. Specific jalap, 10 to 20 drops every 4 hours for its specific uses. Though not an anthelmintic, jalap is often given to hasten the expulsion of worm, after agents have been given for their stupefaction or destruction.

  • Specific Indications and Uses:  Constipation from deficient secretion of intestinal glands; pain and griping in lower bowel; colic, with stercoraceous vomiting; general gastro-intestinal torpor.
  • TAMPICO JALAP:  This is the Mexican Purga de Sierra Gorda, and is derived from the Ipomoea simulans, (Hanbury). It much resembles the jalap tuber in appearance, odor, and taste. While it is difficult to distinguish some of the tubers from those of true jalap, most of the Tampico tubers are smaller and more elongated, more corky and shriveled, and show an absence of little scars crosswise the roots so noticeable in true jalap. It yields a resin (10 to 15 per cent). Fl?ckiger obtained 10 per cent of it. It is completely soluble in ether. Spirgatis (1870) named the resin tampicin. It is converted into tampicic acid by means of concentrated alkalies. Acids resolve it into sugar and tampicolic acid , thus showing its glucosidal character, analogously to that of convolvulin. It has purgative properties.
  • Mirabilis jalapa (Linn?): The tubers of this species, which somewhat resemble jalap, may be distinguished by the presence of needle-like raphides of calcium oxalate.
  • Ipomoea turpethum, (R. Brown): Turpeth root. This is the Turbith v?g?tal of the French Codex. It is not very similar in appearance to jalap. It contains a resin (4 per cent), of which turpethin, the ether-soluble portion, a glucosid, behaves like resin of jalap in relation to acids and alkalies. Bases convert it into turpethic acid, methyl-crotonic acid, traces of formic, and methyl-ethyl-acetic acids, etc.
  • Ipomoea nil, Roth (Convolvulus nil, Linn?; Pharbitis nil, Choisy):  Seeds called kaladana in India, and are slightly purgative. They are black, triangular, with a rounded back, and have a sweetish taste, followed by an acrid sensation. They yield pharbitisin (identical with convolvulin) and a volatile oil. The seeds are roasted and given in powder.
  • Ipomoea triloba (Pharbitis triloba, Ipomoea hederacea):  The seeds of the Japanese plant known as kengashi, yield convolvulin, and are employed like kaladana.
  • MECHOACAN: This product, probably of a convolvulaceous plant, comes in gray or whitish circular sections or fragments, somewhat farinaceous, and destitute of the circles of resinous cells. It sometimes occurs as an adulterant of jalap, but its detection is not difficult. It is feebly cathartic.
  • ORIZABA ROOT. This is variously known as Woody, Light, or Fusiform jalap, Male jalap, Jalap tops or stalks, and is the Mexican Purgo macho. It is derived from the Ipomoea orizabensis, Ledanois. This root is fusiform, and sometimes occurs in commerce in transverse slices, but more frequently in rectangular blocks. Its longitudinal wrinkles are deeper than those of jalap. Its color is also lighter. From the latter it may be known by the radiations on transverse section, and by leaving, when fractured, projecting bundles of fibrous vessels. Chemically, it closely resembles jalap. Its chief constituent is jalapin , so named by Mayer (para-rhodeoretin of Kayser), and should not be confounded with the jalapin of Buchner and Herberger, which is convolvulin. Mayer's jalapin differs from convolvulin in that ether and acetone freely dissolve it. Poleck (1892) proposes for it the name orizabin, as Prof. Maisch has done in 1887. Alkalies change it into water-soluble jalapic acid . Diluted acids convert it into sugar and jalapinol , insoluble in water; probably identical with jalapinolic acid , obtainable from scammony resin. Jalapin (orizabin) is oxidized by nitric acid to carbonic, isobutyric, and ipomic acid, the latter an isomer of sebacic acid (compare convolvulin). Jalapin (Mayer's) has been shown by Spirgatis to be identical with scammonin, both in chemical and purgative qualities, a fact more recently confirmed by Th. Poleck.
  • Ipomoea pandurata, Meyer (Convolvulus panduratus, Linn?):  Wild potato.
    This plant, likewise known as Wild jalap, Man in the Ground, Mechameck, Man of the Earth, etc., has a perennial, very large, tapering root, with several stems from the same root, from 4 to 8 feet long, round, slender, purplish, smooth or nearly so, trailing or twinning. Leaves 2 or 3 inches long, about the same width, broadly cordate at base, acuminate, entire, or wavy, alternate, sometimes panduriform, smooth, deep-green above, paler beneath, on long petioles. Flowers white, dull-purple toward the base, large, opening in the forenoon; peduncles axillary, longer than the petioles, cymose, branching at the top, several-flowered. Corolla large, campanulate, 2 or 3 inches long. Calyx smooth, 5-parted, naked; sepals ovate-oblong stamens white, the length of the tube; anthers oblong. Style white, thread-like; stigma capitate, bilobed. Capsule oblong, 2-celled, 4-seeded, without intermediate partitions (L.?W.?G.).
  • Wild potato is indigenous to the United States, growing in light and sandy soils, from Connecticut and west New York, southward and westward, and flowering from June to August; it rarely grows North, but is found in some parts of South America. The root is the medicinal part, it is very large, being from 2 to 8 feet in length, and from 2 to 4 or 5 inches in diameter, branched at the bottom, brownish-yellow externally, whitish and lactescent internally, furrowed lengthwise, and of a disagreeable odor and bitter, rather acrid taste; about 75 per cent in weight is lost in drying. It is generally met with in transverse, circular sections, which are somewhat tawny externally, whitish with diverging lines internally, and not readily powdered; the powder is somewhat grayish. Water or alcohol extracts its active properties, but diluted alcohol or spirits are its best solvents. It contains resin, bitter-extractive, sugar, starch, gum, a body resembling tannic acid, etc. The resin is purgative. It consists of an acid, and a non acid portion. It is a glucosid, and exists to the extent of 1.5 per cent.

The active principles of this plant are unknown. It possesses mild cathartic properties, acting gently in doses of from 40 to 60 grains of the powdered root. The infusion taken in wineglassful doses every hour, has been effective in dropsy, strangury, and calculous affections. It seems also to exert an influence over the lungs, liver, and kidneys, without excessive diuresis or catharsis. The saturated tincture is more energetic than the powdered root, decoccion, or extract. It is asserted that the Indians can handle rattlesnakes with impunity after wetting their hands with the milky juice of this root.

Copyright: www.prowl.blogfa.com

2007-12-25

 

Posted by نيما ساكتي at | Link To This Post ID 129 | Topic : مقالات انگلیسی DISSERTATION
Abstract

The role of advanced glycation end-products (AGEs) in the development of complications in individuals with insulin-dependent diabetes mellitus (IDDM) has been explored by previous studies. However, the relationship between these reactive AGEs and diabetic complications are still somewhat unknown. Glycation (nonenzymatic glycosylation) processes, also known as the Maillard reactions, are a series of reactions between carbohydrates and free amino groups of proteins. The preliminary intermediates, (Amadori products; 1-amino, 1-deoxy, 2-ketoses), ultimately result in the formation of AGEs. AGEs in humans have been predominantly chemically characterized by the detection of pentosidine and N-carboxy-methyl lysine (CML). Both pentosidine and CML have been found to accumulate in skin and lens collagen matrix at accelerated rates in diabetic patients. Indications are that collagen in IDDM patients undergoes widespread chemical alterations that result in decreased solubility, alter binding affinities to enzymes, increased stability, accelerated cross-linking and increased browning. Accumulation of AGEs with structural alterations result in altered tissue properties that contribute to the reduced susceptibility to catabolism and to the aging of tissues. Also, when accelerated by hyperglycemia, AGE accumulation is believed to contribute to the gradual development of diabetic complications. Pentosidine concentrations in the skin of IDDM patients are often elevated and correlate to the severity of complications. It has also been suggested that pentosidine is not just a subset of diabetic complications but rather a general diagnostic feature of the disease process.

Introduction

The pathogenesis of diabetic complications continues to be a central issue in current diabetes research (15). One of the most prevalent metabolic syndromes world-wide, diabetes mellitus (DM), is characterized by hyperglycemia resulting in short-term metabolic changes in lipid and protein metabolism and long-term irreversible vascular and connective-tissue changes. These changes include diabetes-specific complications such as retinopathy, nephropathy and neuropathy and complications of the macro-vasculature such as atherosclerosis; potentially resulting in heart disease, stroke and peripheral vascular disease (11). Links between chronic hyperglycemia and the development of long-term diabetic-specific complications have been discovered and are yet not completely understood (11, 23).

[b]Figure 1.[/b] Structure of fluorophore P (Pentosidine).
Figure 1. Structure of fluorophore P (Pentosidine). (Click image for larger version)


Glycation, a chemical modification of proteins with reducing sugars, indicates a possible explanation for the association (7, 15) between hyperglycemia and the wide variety of tissue pathologies. Research suggests that reducing sugars can react with the amino groups of long-lived proteins to produce non-enzymatic cross-links (19, 23). Formations of these cross-links occur as end-stage products of the Maillard reaction; they are known as advanced glycation end-products (AGEs) (7, 20).

AGEs are a class of complex, often unstable, reactive compounds formed in excess during aging and diabetes mellitus (23). According to the “glycation hypothesis,” accumulation of AGEs alters the structural properties of tissue proteins and reduces their susceptibility to catabolism (7, 23). It has been shown that the process of AGE formation is accelerated by hyperglycemia (4, 7, 16). Some of the protein alterations observed in diabetic patients resemble those in much older, non-diabetic patients, suggesting ‘diabetes induced early aging’ (20).

The chemical nature of AGEs in vivo is largely unknown, but there is a growing population of structurally-defined AGE adducts such as pyrraline, pentosidine, N-carboxy-methyl lysine (CML) and crossline that are found to be elevated in diabetic tissues (7, 15, 21). The best found chemically characterized AGEs in humans are pentosidine and CML (see Figures 1, 2) (16, 23). Some of the highest levels of pentosidine have been detected in individuals afflicted with DM (19). Evidence has shown that elevated skin pentosidine levels in individuals with DM correlate with the severity of the complications (19). Initial investigations have shown that pentosidine can be detected in smaller levels in various tissues of noncollagenous origin, including the blood and the human lens (19).

[b]Figure 2.[/b] Structure of carboxyl methyl lysine (CML).
Figure 2. Structure of carboxyl methyl lysine (CML). (Click image for larger version)


Pentosidine is a fluorescent crosslink with visible wave length fluorescence, making it easy to detect (15). Methods for synthesizing and detecting AGEs such as pentosidine have been proposed in various studies (7, 14, 19). Prevention of AGE-mediated cell toxicity has been proposed as a key strategy in preventing the onset of diabetic complications and some age-related pathology (21). This review will continue to analyze evidence that AGEs play a significant role in diabetic complications considering various anti-AGE therapeutic strategies that appear to reduce the severity and onset of complications (4, 10, 12, 13, 15, 23).

Long-Term Complications Due to AGEs

Protein glycation and AGE formation are accompanied by increased free radical activity that contributes to the bimolecular damage in diabetes (1, 13, 23). AGEs act as mediators and can initiate a wide range of abnormal responses in cells and tissues such as the inappropriate expression of growth factors, alterations in growth dynamics, accumulation of extra-cellular matrix and initiation of cell death (21, 23), through decreased solubility, elasticity and enzymatic affinities in long-living proteins such as collagen (8, 15).

A number of these chemical and physical skin changes occur in human skin collagen with age and appear to be accelerated in diabetes (12, 13). AGE cross-linking reactions in collagen contributes to diabetic circulatory complications such as vascular stiffening and myocardial dysfunction (22, 23). Although the mechanisms underlying the development of the complications of diabetes are not fully understood, there is now a consensus that hyperglycemia does play an important role in the development of retinopathy, nephropathy, neuropathy and joint stiffness (10, 13). For example, increased serum and tissue levels of AGEs due to a reduced removal by the kidneys have been evident in end-stage renal failure (23). In vitro and in vivo studies have shown that AGEs result in irreversible cross-links in long living matrix structural proteins such as type IV collagen, laminin and fibronectin (23).

Biochemistry of AGEs

The formation of AGEs is implicated by the pathogenesis of long-term complications of diabetes (3, 6). There appears to be two general pathophysiologic mechanisms by which hyperglycemia leads to irreversible tissue damage (4). Intracellular hyperglycemia can result by increased flux through different metabolic pathways, changing glomerular basement membrane. Increases in the polyol pathway activity results in metabolic changes too, consequence of decreasing levels of NADPH, gluthathione and myoinositol (4).

A major consequence of hyperglycemia is excessive nonenzymatic glycosylation of proteins (3, 4, 10), primarily due to long-term exposure to elevated glucose concentrations (12). Nonenzymatic glycation may be occurring, although at a much slower rate than that seen most in IDDM patients (3). Nonenzymatic protein glycation (Mallard Reaction) by glucose is a complex cascade of condensations, rearrangements, fragmentations and oxidative modifications (3). Glucose chemically attaches to proteins and nucleic acids without the aid of enzymes, increasing the formation of AGEs (4). These AGEs form on intra- and extracellular proteins, lipids, and nucleic acids, leading to the generation of protein fluorescene and the irreversible cross-links (1, 11, 15). The formation of AGEs requires the reaction of reducing sugars like glucose, fructose, galactose, mannose and ribose (22). Interestingly, glucose is among the least reactive of the common sugars, perhaps leading to its evolutionary selection as the principle free sugar in vivo (1, 22).

For a given protein, the extent of nonenzymatic glycosylation is determined by the sum of effects of a number of independently acting variables such as pH, temperature, protein concentration, etc. (4, 9). Glucose concentration and incubation time are the most clinically relevant variables affecting the extent of nonenzymatic glycosylation (4). Characteristic to diabetics, increased levels of glucose concentrations cause the level of accumulated Amadori products on proteins to rise (4).

Non-enzymatic glycosylaton is a common posttranslational modification of proteins in vivo, resulting from reactions between glucose and amino groups on proteins, this process is coined the “Maillard reaction” and results in the formation of AGEs (1, 8, 11, 15, 23).

The Maillard Reaction (Non-enzymatic glycosylation)

AGEs form via a non-enzymatic condensation reaction between reducing sugars and -amino group or N-terminal groups (7, 10, 15, 16, 21-23) via a neucleophilic addition with formation of a Schiff base (1, 4). The Schiff base rapidly reaches an equilibrium level in vivo, reflecting the surrounding glucose concentration.

The chemically unstable Schiff bases form relatively fast and are highly reversible (4, 21, 22). Over a period of weeks, a slow chemical rearrangement of the Schiff base occurs, resulting in the formation of stable yet highly reversible ketoamine (Amadori product), an initial reaction product and intermediate in the formation of AGEs (1-5, 21, 22). Amadori adduct formation is slower but much faster than the reverse reaction, leading to accumulation of Amadori glycation products on various proteins (4, 21, 22). Reactive AGE-forming intermediates can arise from oxidative reactions (“glycoxidation”) of free sugar or from initial Schiff base condensation products with protein amino groups, rather than just from the “classical” Amadori rearrangement (3). The presence of AGE cross-links in collagen is suggested to contribute to the severity of diabetic complications (1, 6, 12) although the degree to how much these relate is unknown.

Adducts of Glycation

The chemical nature of important AGEs as they occur in vivo is largely unknown due to their heterogeneous and unstable nature; however, there is a growing population of structurally defined AGE adducts such as pyrraline, pentosidine and CML, all of which have been found at elevated levels in diabetics (1, 4, 21). The two most commonly measured AGEs are CML and pentosidine, which are glycoxidation products, formed by sequential glycation and oxidation reactions (3). The adduct formed by glycation of lysine residues in protein is termed fructoselysine (FL) (see Figure 3), and levels of FL in hemoglobin, plasma proteins, collagen, hair, lens and numerous other proteins in the body are also known to increase in proportion to the degree of hyperglycemia in diabetes (8).

[b]Figure 3.[/b] Structure formed by glycation of lysine residues in protein, fructoselysine (FL).
Figure 3. Structure formed by glycation of lysine residues in protein, fructoselysine (FL). (Click image for larger version)


Early studies of nonenzymatic glycosylation showed that this process ultimately gives rise to pigmented, fluorescent and glucose-derived protein crosslinks (4). These pigmented, fluorescent compounds have been used to study the relationship between AGE formation and various tissue pathologies (2, 17, 19). Along with the brown color, fluorescence is one of the qualitative properties of AGEs (22). The fluorescent AGE crosslink pentosidine was first isolated and identified from dura mater collagen and has been identified in vivo in skin collagen and plasma proteins of diabetic patients (3, 7, 22).

Pentosidine Formation and Significance

Pentosidine has been detected and measured in tissue proteins by chemical and chromatographic methods (2, 17, 19). Pentosidine is unique in that it can be formed by the reaction of lysine and arginine, forming a fluorescent crosslink with any of several carbohydrate precursors including glucose, ribose, ascorbic acid, and 3-deoxyglucosone (see Figure 2) (7, 22). The development of increased fluorescence of proteins in diabetes and aging is enhanced by oxidation reactions and carbohydrate or lipid-dependent processes (7). It has been proposed that AGEs such as pentosidine are in fact active intermediates in the cross-linking of proteins and formation of reactive oxygen species (2).

Pentosdine has been found in a variety of tissues of human origin including skin, tracheal cartilage, cortical bone, aorta, cardiac muscle, lung, liver, kidney, lens, red blood cells, and blood proteins (19). Pentosidine has been found to accumulate in the skin and lens at accelerated rates in diabetics (11, 15). Overall, correlations between skin pentosidine levels and the severity of long-term complications indicate that pentosidine parallels severity (19). Formation of elevated skin pentosidine levels in IDDM patients with severe complications, although unclear, has been associated to poorer metabolic control compared to those with less severe complications (19). Therefore, skin pentosidine would be formed primarily from glycated skin collagen and should reflect cumulative glycohemoglobin AIC values which are now a chemically accepted indicator of glycemic control (4, 7).

Preventative Measures

Poor metabolic control and other characteristics of IDDM result in diabetic nephropathy, neuropathy, retinopathy, atherosclerosis and difficulty in healing wounds (1). Preventative measures for clinical problems that may be the result of accelerated AGE production with IDDM include improvement of glycemic control (4, 10). Recent studies have shown that when the quality of patient control is good (for example, patients who maintain a normal blood-glucose level) the concentrations of the AGE-products, CML and pentosidine, are typically lower (18). However, recent clinical trials suggest that when complications are already present, improvement of glycemic control alone may not be sufficient to prevent the continued progression of these pathologic processes, potentially due to the irreversibility of AGE formation as well as poor clearance mechanisms.

[b]Figure 4.[/b] Aminoguanadine (AG), a structurally identified AGE inhibitor.
Figure 4. Aminoguanadine (AG), a structurally identified AGE inhibitor. (Click image for larger version)


AGE inhibitors

Due to detrimental effects of AGEs, researchers attempt to find inhibitors of the advanced glycation process (6).Brownlee et al. suggest that optimal future therapies to minimize tissue damage may require pharmacologic agents that directly interfere with the self-perpetuating component of hyperglycemia-initiated tissue damage (4). Aminoguanadine (AG) (see Figure 4), an inhibitor of advanced glycation reactions in vitro, has been found to inhibit the development of diabetic complications in animal models of diabetes. (4, 12). Booth et al. suggest that these inhibitors can potentially react as a hydrazine with carbonyls of Amadori intermediates or can hunt for reactive dicarbonyls through its guanidinium moiety. However, the mechanism of AGE formation is only partially understood, making it difficult to identify the precise chemical products responsible for in vivo damage and thus impede the development of specific inhibitors.

Summary

A major consequence of hyperglycemia is excessive non-enzymatic glycosylation of proteins resulting in various protein-protein cross-links and non-crosslinked structures (4, 10, 22). AGE products contribute to long term complications of IDDM patients (2, 4, 17, 19). With the increasing rate of occurrence of IDDM, it is important to increase knowledge about AGEs and AGE-inhibitors. Through research it may be possible and beneficial to find substances that can be used to decrease or predict the occurrence of long term complications of AGE formation to improve the quality and length of life for IDDM patients.

References

1. Ahmed, N. (2005) Advanced glycation end products—role in pathology of diabetic complications. Diabetes Research and Clinical Practice 67, 3-21.

2. Baynes J. et al. (1999) Role of oxidative stress in diabetic complications. Diabetes 48, 1-9.

3. Booth A. et al. (1997) In vitro kenetic studies of formation of antigenic advanced glycation end products (AGEs). Journal of Biological Chemistry 272, 5430-5437.

4. Brownlee, M. et al. (1984). Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Annals of Internal Medicine 101, 527-537.

5. Chellan P, et al. (2001) Early glycation products produce pentosidine cross-links on native proteins. Journal of Biological Chemistry 276, 3895-3903.

6. Degenhardt, T. et al. (1999) Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-prodcuts in skin collagen of diabetic rats. Diabetes research and clinical practice 43, 81-89.

7. Dyer, D.G. (1993) Accumulation of maillard reaction products in skin collagen in diabetes and aging. Journal of Clinical Investigation 91, 2463-2469.

8. Dunn, J. et al. (1989). Oxidation of glycation proteins: age-dependent accumulation of N-(carboxylmethyl)lysine in lens proteins. Biochemistry 28, 9464-9468.

9. Eble, A.S. et al. (1983) Nonenzymatic glucose and glucose-dependent crosslinking or protein. Journal of Biological Chemistry 10, 9406-9412.

10. Forbes J. M. et al. (2003). Role of advanced glycation end products in diabetic nephropathy. Journal of American Society of Nephrology 14, S254-S258.

11. Hudson, J. et al. (2002) Glycation and diabetes:The RAGE connection. Current Science 83, 1515-1521.

12. Kochakian, M. (1996) Chronic dosing with aminoguanidine and novel advanced glycosylation end product-formation inhibitors ameliorates cross-linking of tail tendon collagen in STZ-induced diabetic rats. Diabetes 45, 1694-1700.

13. Lyons, T. et al. (1991). Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus. Journal of Clinical Investigation 87, 1910-1915.

14. Maurizio, S. et al. (1995). Role of advanced glycation end-products (AGE) in late diabetic complications. Diabetes Research and Clinical Practice 28, 9-17.

15. McCance, D. et al. (1993) Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus. Journal of Clinical Investigators 91, 2470-2478.

16. Price, D. et al. (2001) Chelating activity of adcanced glycation end-product inhibitors. Journal of Biological Chemistry 276, 48967-48972.

17. Sajithlal, G. et al. (1998) Advanced glycation end products induce crosslinking of collagen in vitro. Biochimica et biophyisica Acta 1407, 215-224.

18. Schiel, R. et al. (2003) Improvement of the quality of diabetes control and decrease in the concentration of AGE-products in patients with type 1 and insulin-treated type 2 diabetes mellitus studied over a period of 10 years (JEVIN). Journal of Diabetes and Its Complications 17, 90-97.

19. Sell, D. et al. (1991) Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes/Metabolisim Reviews 7, 239-251.

20. Sensi, M. et al. (1995) Role of advanced glycation end-products (AGE) in late diabetic complications. Diabetes Research and Clinical Practice 28, 9-17.

21. Stitt, A.W. (2001) Advanced glycation: an important pathological even in diabetic and age related ocular disease. British Journal of Ophthalomol 85, 746-753.

22. Ulrich, P and Cerami A. (2001) Protein glycation, diabetes and aging. Recent Progress in Hormone Research 56, 1-22.

23. Wautier, J.L. and Guillausseau, P.J (2001) Advanced glycation end products, their receptors and diabetic angiopathy. Diabetes Metabolism 27, 535-542.
 
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HMS Onslow & HMS Pakenham
the 1/700 Tamiya 'O' Class Destroyer

By: Keith Butterley


History
The 'O' and 'P' class destroyers were the first of their kind built under the Emergency War Programme. They were born of the need for the Royal Navy to quickly replace many of its aging destroyers due to the clouds of war gathering in Europe. It was decided in an effort to cut costs and building time, that they would use the same machinery as the 'J' class, but with a simpler armament. These ships were designed for general fleet, patrol and escort duties. The 'O' class was ordered on September 3, 1939, with the HMS Oribi being the first completed in July 1941. Other ships were the Obdurate, Obedient, Offa, Onslaught, Onslow (leader), Opportune and Orwell. The similiar 'P' class was ordered on October 20, 1939, with the HMS Porcupine being finished in June 1941. The rest of the class was Pakenham (leader), Paladin, Panther, Partridge, Pathfinder, Penn and Petard.

All these ships served with distinction throughout the war. Their most famous action occurred in December 1942, while escorting convoy JW51B the Onslow, Obedient, Orwell, Obdurate, Oribi and the 'A' class destroyer Achates held off the Lutzow, Hipper and six KM destroyers for six hours. Finally HM cruisers Jamaica and Sheffield arrived and finally drove the Germans off, without loss. The Paladin, Oribi and Onslow were also responsible for individual U-boat kills, while the Pakenham and Petard shared one. The Pakenham, Panther and Porcupine were all lost while in the Mediterranean.

The Tamiya kit builds up to a fairly good representation of this class. However out of the box they can only be built as the two leaders, Onslow and Pakenham, modification of the aft gun house is required to do other members of the class. I relied heavily on Nat Richards' article from the IPMS Quarterly Review to make the changes in the kit that was necessary to make an accurate leader. The White Ensign Models O Class PE set was used to give them that much needed extra detail. To bring the kit up to a proper 1/700 scale, you need to lengthen the hull 1mm., however I chose not to do this, too scary! I scratch-built the RDF shacks, behind the bridge using plastic card, as they did not come with the kit. The splinter shields around the 4" HA gun were filed away and replaced them with PE fret. I am sure that if scaled out the originals would have been akin to Maginot Line fortifications.


HMS Pakenham

I chose to model the HMS Onslow with her lattice mast. This was added during her re-fit after the Barents Sea battle. I painted her in the Special home Fleet Destroyer Design white/G45/G20/B30. This scheme required a lot of masking due to its many sharp angle lines, but it certainly turns the kit into quite a stunning model. The Pakenham was done in a Western Approaches scheme WA blue/white. To the best of my knowledge she never carried this scheme, but I have always liked it, so there !!!


This kit does require a lot of work to make a decent model, but with the addition of the morePE set and the modifications per Nat Richards, it can be turned into a very good model.

Copyright © prowl2003

Posted by نيما ساكتي at | Link To This Post ID 126 | Topic : مقالات انگلیسی DISSERTATION

بانک نت

گيتار کلاسيک

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سايتهاي مرجع:

http://partituras.8m.com/

http://archive.digitalguitararchive.com

http://www.klassiskgitar.net/freescores.html

http://www.free-scores.com

http://www.eythorsson.com

http://www.delcamp.net/classicalguitar/sheetmusic.html

http://dirk.meineke.free.fr

http://www.e-tabs.org ( تبلچر)

Posted by نيما ساكتي at | Link To This Post ID 125 | Topic : بانک نت (note bank)

 

جشن سنتی Zambomba Flamenca در Jerez (Cádiz).

در اندلوسیا نمیتوان از جشنهای مذهبی کریسمس به سادگی گذشت جشنی با اصالت و مردمی که موسیقی فلامنکو نیز در بطن این جشن وجود دارد. این جشن که معمولا در گذشته در حیاط یکی از اهالی محل برگزار می شد و همراه با رقص و آواز بود را به اصطلاح zambombas مینامند و این بخاطر این است که مردم اندلس کریسمس را با به صدا در اوردن وسایلی مانند زدن دایره و زنگوله و بهم زدن قاشق و ایجاد صداهایی از این قبیل جشن میگیرند.

 


[برای دیدن ادامه کلیک کنید.]
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Geyser

 

 
Struttura a sifone
Struttura a sifone
Geysir in Cile
Geyser Strokkur in Islanda
Geyser Strokkur in Islanda

Il geyser è una tipologia di sorgente di acqua calda che ha delle eruzioni periodiche che creano delle colonne di acqua calda e vapore. Il nome geyser deriva da Geysir che è il nome del più noto geyser islandese.

Essi sono una manifestazione del vulcanismo secondario, che si ha quando è presente una caratteristica struttura a sifone. In essa ci sono rocce permeabili, nelle quali circola l'acqua, dirette prima verso il basso e poi verso l'alto, circondate da rocce impermeabili, e nelle vicinanze è poi posta una camera magmatica. L'acqua entra nella struttura a sifone ed è riscaldata a causa della vicina camera magmatica, ma la profondità e la conseguente pressione litostatica impediscono che essa diventi vapore. In seguito risale in superficie e, con una pressione minore, l'acqua e il vapore sono liberi di esplodere in getti periodici. Il periodo è dovuto proprio al tempo necessario affinché il sifone si riempia.

I geyser sono abbastanza rari in quanto richiedono una combinazione di caratteri geologici e climatici che esistono solo in poche aree. Ci sono sei zone nelle quali si trovano molti geyser:

Si trovano in prossimità di vulcani o nei luoghi ove la crosta terrestre è meno spessa.

Tra i geyser più famosi vi sono quelli situati in Islanda ove vi è il Gran Geyser, che ha dato universalmente il nome al fenomeno, con getti alti da 30 a 40 metri. Cominciò la sua attività nel XIV secolo per cessare all'inizio del XX secolo. Fortunatamente sopravvive il vicino Strokkur, i cui getti raggiungono i venti metri: hanno una frequenza di circa cinque/otto minuti e i salti dell'acqua possono essere spettacolarmente due o tre. Intorno al sito si trovano altre sorgenti di acqua calda, il Piccolo Geysir, torrenti caldi e depositi minerali che rendono la zona simile a quella di "un altro pianeta": vedere per credere.

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Posted by نيما ساكتي at | Link To This Post ID 123 | Topic : مقالات اسپانیاییspanish resarch

Geyser

 

 
Strokkur geyser, Iceland
Strokkur geyser, Iceland

A geyser is a type of hot spring that erupts periodically, ejecting a column of hot water and steam into the air. The name geyser comes from Geysir, the name of an erupting spring at Haukadalur, Iceland; that name, in turn, comes from the Icelandic verb gjósa, “to gush”.

The formation of geysers requires a favourable hydrogeology which exists in only a few places on Earth, and so they are fairly rare phenomena. About 1,000 exist worldwide, with about half of these in Yellowstone National Park, U.S..[1] Geyser eruptive activity may change or cease due to ongoing mineral deposition within the geyser plumbing, exchange of functions with nearby hot springs, earthquake influences, and human intervention.[2]

Erupting fountains of liquefied nitrogen have been observed on Neptune's moon Triton, as have possible signs of carbon dioxide eruptions from Mars' south polar ice cap. These phenomena are also often referred to as geysers. Instead of being driven by geothermal energy, they seem to rely on solar heating aided by a kind of solid-state greenhouse effect. On Triton, the nitrogen may erupt to heights of 8 km.

Contents

[hide]

[ Eruptions

1. Steam rises from heated water
2. Pulses of water swell upward
3. Surface is broken
4. Ejected water spouts upward and falls back

Geyser activity, like all hot spring activity, is caused by surface water gradually seeping down through the ground until it meets rock heated by magma. The geothermally heated water then rises back toward the surface by convection through porous and fractured rock. Geysers differ from noneruptive hot springs in their subterranean structure; many consist of a small vent at the surface connected to one or more narrow tubes that lead to underground reservoirs of water.

As the geyser fills, the water at the top of the column cools off, but because of the narrowness of the channel, convective cooling of the water in the reservoir is impossible. The cooler water above presses down on the hotter water beneath, not unlike the lid of a pressure cooker, allowing the water in the reservoir to become superheated, i.e. to remain liquid at temperatures well above the boiling point.

Ultimately, the temperatures near the bottom of the geyser rise to a point where boiling begins; steam bubbles rise to the top of the column. As they burst through the geyser's vent, some water overflows or splashes out, reducing the weight of the column and thus the pressure on the water underneath. With this release of pressure, the superheated water flashes into steam, boiling violently throughout the column. The resulting froth of expanding steam and hot water then sprays out of the geyser hole.

Eventually the water remaining in the geyser cools back to below the boiling point and the eruption ends; heated groundwater begins seeping back into the reservoir, and the whole cycle begins again. The duration of eruptions and time between successive eruptions vary greatly from geyser to geyser; Strokkur in Iceland erupts for a few seconds every few minutes, while Grand Geyser in the U.S. erupts for up to 10 minutes every 8–12 hours.

[ Types of geysers

Vixen Geyser in Yellowstone
Vixen Geyser in Yellowstone

There are two types of geysers: fountain geysers erupt from pools of water, typically in a series of intense, even violent, bursts; and cone geysers which erupt from cones or mounds of siliceous sinter (also known as geyserite), usually in steady jets that last anywhere from a few seconds to several minutes. Old Faithful, perhaps the best-known geyser at Yellowstone National Park, is an example of a cone geyser. Grand Geyser, the tallest predictable geyser on earth, also at Yellowstone National Park, is an example of a fountain geyser.

The intense transient forces inside erupting geysers are the main reason for their rarity. There are many volcanic areas in the world that have hot springs, mud pots and fumaroles, but very few with geysers. This is because in most places, even where other necessary conditions for geyser activity exist, the rock structure is loose, and eruptions will erode the channels and rapidly destroy any nascent geysers.

Most geysers form in places where there is volcanic rhyolite rock which dissolves in hot water and forms mineral deposits called siliceous sinter, or geyserite, along the inside of the plumbing systems. Over time these deposits cement the rock together tightly, strengthening the channel walls and enabling the geyser to persist.

Geysers are fragile phenomena and if conditions change, they can ‘die’. Many geysers have been destroyed by people throwing litter and debris into them; others have ceased to erupt due to dewatering by geothermal power plants. The Great Geysir of Iceland has had periods of activity and dormancy. During its long dormant periods, eruptions were sometimes humanly-induced — often on special occasions — by the addition of surfactants to the water. Inducing eruptions at Geysir is no longer done, as the forced eruptions were damaging the geyser's special plumbing system. Following an earthquake in Iceland in 2000 the geyser became somewhat more active again. Initially the geyser erupted about eight times a day. As of July 2003, Geysir erupts several times a week.

Hyperthermophiles produce some of the bright colors of Grand Prismatic Spring, Yellowstone National Park
Hyperthermophiles produce some of the bright colors of Grand Prismatic Spring, Yellowstone National Park

[ Biology of geysers

Main article: Thermophile, Hyperthermophile.

The specific colours of geysers derive from the fact that despite the apparently harsh conditions, life is often found in them (and also in other hot habitats) in the form of thermophilic prokaryotes. No known eukaryote can survive over 60 °C (140 °F).

In the 1960s, when the research of biology of geysers first appeared, scientists were generally convinced that no life can survive above around 73 °C (163 °F)—the upper limit for the survival of cyanobacteria, as the structure of key cellular proteins and deoxyribonucleic acid (DNA) would be destroyed. The optimal temperature for thermophilic bacteria was placed even lower, around 55 °C (131 °F).[citation needed]

However, the observations proved that it actually is possible for life to exist at high temperatures and that some bacteria prefer even temperatures higher than boiling point of water. Dozens of such bacteria are known nowadays.[citation needed] Thermophiles prefer temperatures from 50 to 70 °C whilst hyperthermophiles grow better at temperatures as high as 80 to 110 °C. As they have heat-stable enzymes that retain their activity even at high temperatures, they have been used as a source of thermostable tools, that are important in medicine and biotechnology, for example in manufacturing antibiotics, plastics, detergents (by the use of heat-stable enzymes lipases, pullulanases and proteases), and fermentation products (for example ethanol is produced).[citation needed] The fact that such bacteria exist also stretches our imagination about life on other celestial bodies, both inside and outside of solar system. Among these, the first discovered and the most important for biotechnology is Thermus aquaticus.[citation needed]

 Numbers and distribution

Eruption of White Dome Geyser in Yellowstone
Eruption of White Dome Geyser in Yellowstone

Geysers are quite rare, requiring a combination of water, heat, and fortuitous plumbing. The combination exists in few places on Earth. The five largest geyser fields in the world are:[3]

  1. Yellowstone National Park, Wyoming, United States, North America
  2. Dolina Geiserov, Kamchatka Peninsula, Russia, Asia - partially destroyed by a mudslide on June 3, 2007.
  3. El Tatio, Atacama Desert, Chile, South America
  4. Taupo Volcanic Zone, North Island, New Zealand, Oceania
  5. Iceland, Europe

There used to be two large geysers fields in NevadaBeowawe and Steamboat Springs — but they were destroyed by the installation of nearby geothermal power plants. At the plants, geothermal drilling reduced the available heat and lowered the local water table to the point that geyser activity could no longer be sustained. There are more individual geysers around the world, in California, Peru, Bolivia, Mexico, Dominica, Azores, Kenya, Slovakia and Japan, but no other large clusters.

Yellowstone is the largest geyser locale, containing thousands of hot springs, and between three and five hundred geysers. Yellowstone includes the tallest active geyser (Steamboat Geyser in Norris Geyser Basin), as well as the renowned Old Faithful Geyser, Beehive Geyser, Giantess Geyser, Lion Geyser, Plume Geyser, Aurum Geyser, Castle Geyser, Sawmill Geyser, Grand Geyser, Oblong Geyser, Giant Geyser, Daisy Geyser, Grotto Geyser, Fan & Mortar Geysers, & Riverside Geyser, all in the Upper Geyser Basin.

Many of New Zealand’s geysers have been destroyed by humans in the last century. Several New Zealand geysers have also become dormant or extinct by natural means. The main remaining field is Whakarewarewa at Rotorua. Two thirds of the geysers at Orakei Korako were flooded by the Ohakuri hydroelectric dam in 1961. The Wairakei field was lost to a geothermal power plant in 1958. The Taupo Spa field was lost when the Waikato River level was deliberately altered in the 1950s. The Rotomahana field was destroyed by the Mount Tarawera eruption in 1886. Waimangu Geyser, which existed from 1900 to 1904, was the largest geyser ever known. It ceased to erupt after a landslide covered its crater. Small numbers of geysers still exist at other places within the Taupo Volcanic Zone including Ketetahi, Tokaanu and Wai-O-Tapu.

 Misnamed geysers

In a number of places where there is geothermal activity wells have been drilled and fitted with impermeable casements that allow them to erupt like geysers. Though these so-called artificial geysers, technically known as erupting geothermal wells, are not true geysers, they can be quite spectacular. Little Old Faithful Geyser, in Calistoga, California, is probably an erupting geothermal well.[citation needed]

Sometimes drilled cold-water wells erupt in a geyser-like manner due to the build-up of pressure from dissolved carbon dioxide in the water. These are not true geysers either, but are often called cold-water geysers. The best known of these is probably Crystal Geyser, near Green River, Utah.[4]

A perpetual spouter is a natural hot spring that spouts water constantly. Some of these are incorrectly called geysers, but because they are not periodic in nature they are not considered true geysers.

[edit] Geysers on Triton

Dark streaks deposited by geysers on Triton
Dark streaks deposited by geysers on Triton

One of the great surprises of the Voyager 2 flyby of Neptune in 1989 was the discovery of geysers on its moon, Triton. Astronomers noticed dark plumes rising to some 8 km above the surface, and depositing material up to 150 km downstream.

All the geysers observed were located between 40° and 60°S, the part of Triton's surface close to the subsolar point. This indicates that solar heating, although very weak at Triton's great distance from the Sun, probably plays a crucial role. It is thought that the surface of Triton probably consists of a semi-transparent layer of frozen nitrogen, which creates a kind of greenhouse effect, heating the frozen material beneath it until it breaks the surface in an eruption. A temperature increase of just 4 K above the ambient surface temperature of 38 K could drive eruptions to the heights observed.

Geothermal energy may also be important. Unusually for a major satellite, Triton orbits Neptune in a retrograde orbit—that is, in the opposite direction to Neptune's rotation. This generates tidal forces which are causing Triton's orbit to decay, so that in several billion years time it will reach its Roche limit [1] with Neptune. The tidal forces may also generate heat inside Triton, in the same way as Jupiter's gravity generates tidal forces on Io which drive its extreme volcanic activity.

Each eruption of a Triton geyser may last up to a year, and during this time about 0.1 km³ of material may be deposited downwind. Voyager's images of Triton's southern hemisphere show many streaks of dark material laid down by geyser activity.

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Posted by نيما ساكتي at | Link To This Post ID 122 | Topic : مقالات انگلیسی DISSERTATION
developmental biology


"Views of a Fetus in the Womb", Leonardo da Vinci, ca. 1510-1512. The subject of prenatal development is a major subset of developmental biology.
Enlarge
"Views of a Fetus in the Womb", Leonardo da Vinci, ca. 1510-1512. The subject of prenatal development is a major subset of developmental biology.

Developmental biology is the study of the process by which organisms grow and develop. Modern developmental biology studies the genetic control of cell growth, differentiation and "morphogenesis," which is the process that gives rise to tissues, organs and anatomy. Embryology is a subfield, the study of organisms between the one-cell stage (generally, the zygote) and the end of the embryonic stage, which is not necessarily the beginning of a free living organism. Embryology was originally a more descriptive science until the 20th century. Embryology and developmental biology today deal with the various steps necessary for the correct and complete formation of the body of a living organism.

The related field of evolutionary developmental biology was formed largely in the 1990s and is a synthesis of findings from molecular developmental biology and evolutionary biology which considers the diversity of organismal form in an evolutionary context.

The findings of developmental biology can help to understand developmental malfunctions such as chromosomal aberrations, for example, Down syndrome. An understanding of the specialization of cells during embryogenesis may yield information on how to specialize stem cells to specific tissues and organs, which could lead to the specific cloning of organs for medical purposes. Another biologically important process that occurs during development is apoptosis - programmed cell death or "suicide". For this reason, many developmental models are used to elucidate the physiology and molecular basis of this cellular process. Similarily, a deeper understanding of developmental biology can foster greater progress in the treatment of congenital disorders and diseases, e.g. studying human sex determination can lead to treatment for disorders such as congenital adrenal hyperplasia.


Molecular mechanisms of development

During the second half of the 20th century the types of molecules involved in embryonic development were identified. Transcription factors are the key regulators of which genes are expressed in cells. Transcriptional control in the various differentiated cell types allows each type of cell (epithelial, muscle, neuron, etc) to express different amounts of the possible proteins. The transcription factors are regulated by signal transduction pathways that relay signals from outside of cells to the cell nucleus. Signal transduction pathways often involve receptors, receptor ligands and enzymes such as protein kinases. One key class of genes that are differentially regulated by transcription factors in different cell types are genes for cell adhesion proteins. Cell adhesion proteins are among the key regulators of morphogenesis. Functions of these various proteins in development are often elucidated experimentally using gene knockdown techniques in embryos.

Concepts in developmental biology

allantois, amnion, blastocyst, blastomere, blastula, blastulation, chorion, chrysalis, cleavage, embryo, embryogenesis, embryogeny, embryology, extra-embryonic membrane, fetus, gastrula, gastrulation, germ layer, germ plasm, germination, induction, juvenile, larva, maternal effect, metamorphosis, genome, morphogenesis, morula, neoteny, neural development, nymph, ontogeny, oosperm, ovism, paedogenesis, pangenesis, phylogeny, primordium, pupa, rudiment, seed, self-organization, teratology, zygote

Developmental model organisms

Often used model organisms in developmental biology include the following:

Developmental systems biology

Computer simulation of multicellular development is a research methodology to understand the function of the very complex processes involved in the development of organisms. This includes simulation of cell signaling, multicell interactions and regulatory genomic networks in development of multicellular structures and processes (see Biological Physics of the Developing Embryo). Minimal genomes for minimal multicellular organisms may pave the way to understand such complex processes in vivo.

See also

Sources

Posted by نيما ساكتي at | Link To This Post ID 121 | Topic :

Developmental biology

Cell biology protocols
Expert cell biology protocols from Nature Protocols
www.natureprotocols.com
Breast Cancer
Screening and treatments every woman - and man - should know.
 

A large field of investigation that includes the study of all changes associated with an organism as it progresses through the life cycle. The life cycles of all multicellular organisms exhibit many similarities. That is, as an organism progresses from one generation to the next there is a series of common processes: for example, gametogenesis, fertilization, embryogenesis, cell differentiation, tissue differentiation, organogenesis, maturation, growth, reproduction, senescence, and death.

Analysis of all of the events associated with an organism as it progresses through its life cycle employs a multiplicity of approaches. Tremendous strides have been made in describing at the molecular level the developmental process of cell differentiation. However, the molecular control mechanisms which regulate cell differentiation are not known. Tissue and organ differentiation, as well as morphogenesis, are processes which have been described in detail for many situations, but little is known about the physical and chemical nature of the mechanisms involved. A complete understanding of the development of an organism will require an appreciation and comprehension of the changes which occur at all levels of organization as an organism traverses its life cycle.

The major unifying theme in biology is evolution. Not only has evolution led to the wide variety of organisms now present on Earth, but also evolution has modified the initial processes and patterns of development to the diversity of types currently encountered. This evolution of developmental parameters in multicellular organisms began as single-celled organisms became multicellular. The development of a multicellular organism entails a host of problems not faced by a single-celled organism. For example, cells in one part of the aggregate must coordinate their activities with cells in other parts, nutrients and oxygen must be provided to all cells, and water balance must be maintained.

Developmental biologists have focused on two central areas: the processes and associated mechanisms by which cells become different, that is, cell differentiation; and the processes and associated mechanisms by which patterns are created, that is, morphogenesis.

Current theories state that cells become different by expressing different genes. Thus, a liver cell is different from a muscle cell, not because it contains different genes or genetic information, but because it expresses different sets of genes. This explanation of cell differences is based upon the results of three types of experimental analysis. (1) Some plant cells are totipotent; that is, for tobacco, carrot, and a few other plant species, it has been demonstrated that a single cell (not a gamete) can divide and undergo morphogenesis to form a fertile plant. (2) Nuclei from some differentiated animal cells are totipotent. That is, a nucleus from a differentiated cell can be injected into a mature egg which has had its nucleus removed or destroyed, and the injected nucleus can direct normal development of the organism. (3) The sequences of nucleotides in the DNA of all cells in an organism appear to be the same; that is, DNA-DNA hybridization of DNA from different cell types indicates that the different cell types do not have unique DNA base sequences. Since these results indicate that all cells contain the complete genome for an organism, different cell types appear to arise as a result of the expression of unique sets of genes in each cell type. See also Cell differentiation; Developmental genetics; Gene action; Somatic cell genetics.

Initially the cells of a developing embryo are not restricted in their developmental potential or fate, but as embryogenesis proceeds, a cell's developmental potential becomes restricted or fixed. Restriction of developmental fate is called determination. Two mechanisms have been identified that bring about determination. The first involves the presence of unique factors, called cytoplasmic determinants, which are products of the maternal genome and are located in specific areas of some animal eggs. The cells which come to contain these determinants differentiate along specific pathways. The second mechanism is induction, a process by which two tissues interact so that one or both differentiate along specific pathways. A classic example of induction is the action of mesoderm on the overlaying ectoderm in the frog embryo at the time of gastrulation. The mesoderm acts on the ectoderm, causing it to form the neural plate. Only ectoderm of a certain developmental age is capable of responding to the mesoderm, and this ectoderm is said to be competent. See also Embryonic induction.

Developmental biologists have gained substantial insights into the molecular bases for determination in model organisms such as Drosophila. At least three sets of cytoplasmic determinants (maternal gene products) are present in the fly egg: determinants for germ-cell formation, determinants controlling dorsal-ventral polarity, and determinants for the anterior-posterior polarity. Some of these determinants are messenger ribonucleic acids (mRNAs) coding for proteins which are transcriptional regulators (that is, proteins that regulate gene activity).

Morphogenesis involves the production of form and structure by integrating the differentiation of many different cells and cell types into specific spatial patterns. This higher level of organization has been difficult to investigate in terms of establishing mechanisms. The processes of determination, competence, and induction are involved. One of the greatest challenges faced by developmental biologists is to bridge the gap between genes and patterns. It is clear that patterns are a result of gene activity, but the relationship between genes and patterns in most organisms is not well understood. See also Animal morphogenesis; Plant morphogenesis.


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Aquaculture

Aquaculture, the controlled or semi-controlled production of aquatic plants and animals, has increased at double-digit percentage rates since the early 1980s. This increase has been in response to declines in commercial harvests of wild stocks of fish and shellfish. Oceans of the world are currently at maximum sustainable yield. Since the late 1980s, there has been a concerted effort to maintain global commercial harvest of ocean fish at approximately 100 million metric tons (mmt). However, as global population grows, demand for fish and shellfish increases, and the percentage of aquatic products grown in aquaculture must likewise rise to meet the supply of those products. Projections for increased production are in the range of 40–100 mmt of new aquaculture production by about the year 2030. The lower range assumes only increases in world population; the upper figure represents increases in world population plus a 1 percent per year increase in per capita consumption. To put this number in perspective, the 1995 world production figures for soybeans was 137 mmt, swine was 83 mmt, and chickens was 46 mmt. Thus, to meet demand in the first part of the twenty-first century, we must realize significant growth. This increase in production will not be accomplished with a single species.

There are fewer than thirty large species-specific aquaculture industries globally, and the fourteen largest industries are listed in the table. However, there are over twenty-five thousand species of fish and there are estimates that one thousand new species are being evaluated for their culture potential. The small percentage of species raised relative to the total number available is an indication that aquaculture is a new concept in many parts of the world. As a subsistence enterprise, aquaculture has been practiced for over four thousand years. As a series of large industries, aquaculture is less than fifty years old, often stimulated by declining wild stocks of fish. The channel catfish industry, which only began in the late 1960s in the southern United States, is illustrative of a relatively young industry. Today, over 90 percent of the U.S. supply of Atlantic salmon is cultured. In 1980, that figure was a fraction of 1 percent, at most. The global supply and demand characteristics created a good deal of volatility in production, which has only increased over time. Additional factors such as identification of new diseases and movement of those diseases contribute to the volatility in production. Inevitably, as new aquaculture species are brought into culture settings, new diseases are identified that were previously unknown. In the past ten years, new viral diseases have been identified in shrimp and salmon, both of which caused large-scale losses from production facilities.

Table 1

The largest aquaculture industries, by volume, in 1999
Values are in million metric tons
Species Volume
Giant tiger prawn 3,651,782
Pacific cupped oyster 3,312,713
Japanese kelp 3,023,240
Silver carp 2,837,420
Grass carp 2,743,194
Atlantic salmon 2,448,280
Japanese carpet shell 2,194,521
Roho labeo 1,493,884
Rainbow trout 1,350,168
Japanese amberjack 1,282,090
Yesso scallop 1,252,448
Nori 1,249,923
Whiteleg shrimp 1,062,774
Nile tilapia 1,025,739

Of the approximately 25 mmt of global aquaculture production, there are only a few industries that produced over 1 mmt in 1996. Several of the species of Asian carp and the common carp account for the largest industries. Silver carp production was 2.2 mmt, grass carp production was 1.8 mmt, bighead carp production was 1.1 mmt, and common carp production was 1.5 mmt. Virtually all of this production occurred in China with the exception of common carp, which is raised throughout Europe, its native range. Of the species typically available in U.S. markets, pen-raised Atlantic salmon accounted for 0.4 mmt, rainbow trout production for 0.3 mmt, channel catfish production for 0.2 mmt, and tilapia for 0.6 mmt. Production of several invertebrates was significant. Scallop production was 1.0 mmt, shrimp production was 0.9 mmt, oyster production was 1.1 mmt, mussel production was 1.0 mmt, and clam production was 1.0 mmt. Production of brown seaweeds was 4.5 mmt and red seaweed production was 1.6 mmt. Thus, the largest aquaculture industry is the production of brown seaweeds, largely for nonfood use. In the twenty-first century, greater demand will likely result in increased production.

There are only a few production systems in use for aquaculture, and they include earthen ponds, raceways, cages or net pens, and indoor recirculating systems. Earthen ponds or cages placed in existing bodies of water are the oldest production system and the indoor recirculating systems are the newest. For successful culture, considerable technical expertise is required when using a recirculating system. All of the current industries use earthen ponds (catfish, tilapia, Asian carps, shrimp), raceways (rainbow trout), or cages/net pens (Atlantic salmon, yellowtail, an amberjack from Southeast Asia). Producers are experimenting with indoor recirculating systems using a wide variety of species. There are a few successful producers using indoor systems, but the number will inevitably grow as both the systems themselves and information on targeted species increase. Successful aquaculture can be viewed as the correct match of species under a certain set of market conditions with production system. Some species do not tolerate some of the production systems or do not thrive in those systems. Behavioral characteristics of the various species often point toward the appropriate culture systems. For example, sedentary fish (bluegill, catfish, and flounder) should probably be raised in systems without significant water flow (earthen ponds, cages/net pens), whereas those that typically swim a great deal (tuna, trout, and striped bass) can be raised in raceway systems with a constant flow of water.

Fish are generally considered good quality food for human consumption because of the low saturated fat levels and generally high levels of n-3 fatty acids. Fish tend to retain the fatty acids that are in their diet. Thus, we can manipulate the fatty acid concentrations of fish and produce "designer fish" for targeted markets. Further, we can control the fat concentration in muscle through selected feed and produce a low-fat or high-fat fish depending on the demands of the market. Cultured aquatic animals can be safer products for consumption than wild fish because they are raised in a defined environment, and pollutants can be eliminated. Wild fish can be exposed to environmental pollutants and retain those they encounter. Organoleptic properties (taste) of fish and shell-fish raised in aquaculture can be quite different from wild stocks. Fish flavor can be manipulated by dietary ingredients fed to the target species. If the diet contains a relatively high percentage of fish meal, the fish can taste fishier than if the diet contains a relatively high percentage of corn and soybean products. Fish fed the latter diets are often described as "milder" tasting, which is a desirable characteristic in certain markets. There is also a taste consideration with environment. Some species can survive both fresh-and saltwater, but osmoregulation changes to meet the challenges of those environments. This physiological change affects taste because of the chemical compounds used to regulate ionic balance. A good example of this is the freshwater shrimp. When raised in freshwater, taste has been described as mild, whereas if the shrimp is placed in saltwater for one to two weeks, it will taste more like a marine shrimp. Even with these positive attributes, aquaculture is experiencing growing pains.

Culture of aquatic animals produces the same wastes as other animal production industries. The problem is confounded by the fact that those wastes are discharged as rearing water is renewed. There have been incidences of environmental degradation resulting from aquaculture. One of the focal points of aquacultural research is waste management, focusing on phosphorus and nitrogen dynamics originating in the diet. Those efforts, as well as efforts related to siting aquaculture operations, land-use practices, and economic development, have become the focal point of sustainable aquaculture development. Along with the overall focus on sustainability, there are significant concerns about the feed used to achieve aquaculture's successes. Fish meal is a high-quality ingredient, yet it is a finite resource similar to all other species in the oceans. Ingredients made from soybeans, corn, canola, wheat, legumes, peanuts, and barley, as well as the by-products of the brewing industries and animal packing operations, are needed.

Growth of aquaculture in the twenty-first century will most likely be similar to growth in terrestrial animal production seen in the twentieth century. Fish and shell-fish are the last major food item humans still hunt and gather from wild populations. The sustainable nature of aquacultural production probably will be the focal point of research in the early part of the twenty-first century and those results should facilitate the production increases necessary for sufficient quantities of fish and shell-fish in the future.

Bibliography

Adelizi, Paul D., Ronald R. Rosati, Kathleen Warner, Y. Victor Wu, Tim R. Muench, M. Randall White, and Paul B. Brown. "Evaluation of Fish Meal-Free Diets for Rainbow Trout, Oncorhynchus mvkiss." Aquaculture Nutrition 4, no. 4 (1998): 255–262.

Donahue, Darrell W., Robert C. Bayer, John G. Riley, Alfred A. Bushway, Paul B. Brown, Russell A. Hazen, Keith E. Moore, and Dorothy A. Debruyne. "The Effect of Soy-Based Diets on Weight Gain, Shell Hardness, and Flavor of the American Lobster (Homarus americanus)." Journal of Aquatic Food Product Technology 8, no. 3 (1999): 69–77.

Floreto, Eric A. T., Robert C. Bayer, and Paul B. Brown. "The Effects of Soybean-Based Diets, with and without Amino Acid Supplementation, on Growth and Biochemical Composition of Juvenile American Lobster, Homarus americanus." Aquaculture 189 (2000): 211–235.

New, M. B. "Aquaculture and the Capture Fisheries—Balancing the Scales." World Aquaculture 28 (1997): 11–30.

Riche, M., and P. B. Brown. "Incorporation of Plant Protein Feedstuffs into Fish Meal Diets for Rainbow Trout Increases Phosphorus Availability." Aquaculture Nutrition 5 (1999): 101–105.

Twibell, Ronald G., and Paul B. Brown. "Optimum Dietary Crude Protein for Hybrid Tilapia Oreochromis niloticus x O. aureus Fed All-Plant Diets." Journal of the World Aquaculture Society 29 (1998): 9–16.

Twibell, Ronald G., Bruce A. Watkins, Laura Rogers, and Paul B. Brown. "Dietary Conjugated Linoleic Acids Alter Hepatic and Muscle Lipids in Hybrid Striped Bass. Lipids 35 (2000): 155–161.

Wu, Y. Victor, Ronald R. Rosati, and Paul B. Brown. "Effects of Lysine on Growth of Tilapia Fed Diets Rich in Corn Gluten Meal." Cereal Chemistry 75 (1998): 771–774.

Wu, Y. Victor, Kerry W. Tudor, Paul B. Brown, and Ronald R. Rosati. "Substitution of Plant Proteins or Meat and Bone Meal for Fish Meal in Diets of Nile Tilapia. North American Journal of Aquaculture 6 (1999): 58–63.

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